Articles

Diversity in autoimmunity against retinal, neuronal, and axonal antigens in acquired neuro-retinopathy

Autoimmune retinopathies and optic neuropathies are complex disorders of the retina and the optic nerve, in which patients develop autoantibodies (AAbs) against retinal and optic nerve proteins. Autoimmunity m...

Authors: Grazyna Adamus, Lori Brown, Jade Schiffman and Alessandro Iannaccone

Diffuse infiltrative syphilitic retinitis in an HIV-positive patient

Authors: Hassan Toufiqur Rahman and Steven Yeh

Diagnosis and treatment of microsporidial keratoconjunctivitis: literature review and case series

The purpose of this study is to describe the clinical characteristics, microscopic findings, and treatment response to albendazole of microsporidial keratoconjunctivitis among immunocompromised individuals wit...

Authors: Sadik Taju, Yonas Tilahun, Menen Ayalew, Nigus Fikrie, Jakob Schneider and John H. Kempen

Challenging cases discussed by experts: retinal vasculitis following coinfection with HIV and syphilis

A patient with HIV and syphilis presents with bilateral retinal vasculitis and recurrent vitreous hemorrhage. Diagnostic and treatment strategies are discussed.

Authors: Thomas Albini, Janet L. Davis and Claudio D. Tuda

Ocular modifications in a young girl with cryopyrin-associated periodic syndromes responding to interleukin-1 receptor antagonist anakinra

An 8-year-old patient with genetically confirmed chronic infantile neurological cutaneous and articular syndrome was treated with interleukin-1 receptor antagonist, anakinra. She initially presented with recur...

Authors: Celine Terrada, Benedicte Neven, Nathalie Boddaert, Eric H Souied, Anne Marie Prieur, Pierre Quartier, Phuc Lehoang and Bahram Bodaghi

Bacteriologic and plasmid analysis of etiologic agents of conjunctivitis in Lagos, Nigeria

Conjunctivitis, an inflammation of the conjunctiva, is one of the most common eye problems affecting all age groups in Nigeria. A better understanding of its epidemiology and the antibiotic susceptibility of e...

Authors: Bamidele Abiodun Iwalokun, Afolabi Oluwadun, Kehinde Adewale Akinsinde, Mary Theressa Niemogha and Fransisca Obiageri Nwaokorie

Cytomegalovirus retinitis in a seronegative patient with systemic lupus erythematosus on immunosuppressive therapy

The purpose of this study is to report a rare case of cytomegalovirus (CMV) retinitis in a seronegative patient with systemic lupus erythematosus (SLE) on immunosuppressive therapy.

Authors: Aditya Kelkar, Jai Kelkar, Shreekant Kelkar, Shilpa Bhirud and Jyotirmoy Biswas

Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome

The study aims to evaluate a series of patients with initial diagnosis of ocular histoplasmosis syndrome (OHS) with progression and response to treatments consistent with multifocal choroiditis (MFC).

Authors: Elham Hatef, Peykan Turkcuoglu, Mohamed Ibrahim, Yasir Sepah, Matthew Shulman, Jangwon Heo, Jeong Hee Lee, Roomasa Channa, Afsheen Khwaja, Zubir Rentiya, Syed Mahmood Shah, Diana V. Do and Quan Dong Nguyen

Ocular sarcoidosis and tuberculous lymphadenopathy: coincidence or real association

Tuberculosis and sarcoidosis share similarity in histopathologic findings and clinically occur in association with each other occasionally. Tuberculosis should always be ruled out before the diagnosis of sarco...

Authors: Jiun-Yo Lin and Shwu-Jiuan Sheu

Central retinal artery occlusion in Wegener's granulomatosis: a diagnostic dilemma

To report a case of central retinal artery occlusion (CRAO) in a patient with biopsy-verified Wegener's granulomatosis (WG) with positive C-ANCA.

Authors: Virginia Lozano-López, Beatriz Rodríguez-Lozano, María José Losada-Castillo, Esmeralda Delgado-Frías, David Dopazo-Luque and Miguel Serrano-García

Intermediate uveitis in Indian population

Intermediate uveitis (IU) is generally believed to be autoimmune in nature requiring systemic corticosteroid and immunomodulatory therapy. This belief stems from the published reports from the developed countr...

Authors: Swapnil Parchand, Manjari Tandan, Vishali Gupta and Amod Gupta

Evaluation of molecular diagnosis in fungal keratitis. Ten years of experience

The aims of this study were to assess the utility of polymerase chain reaction (PCR) in diagnosing fungal keratitis in the last decade in our center and to review the molecular diagnosis of mycotic keratitis.

Authors: Consuelo Ferrer and Jorge L. Alió

A retrospective review of oral low-dose sirolimus (rapamycin) for the treatment of active uveitis

The purpose of this study is to elicit the role of oral low-dose sirolimus as a corticosteriod-sparing agent for active uveitis.

Authors: Brandon N. Phillips and Keith J. Wroblewski

Unilateral acute idiopathic maculopathy: angiography, optical coherence tomography and microperimetry findings

Unilateral acute idiopathic maculopathy (UAIM) is an uncommon inflammatory disease of the retinal pigment epithelium (RPE) that affects young adults. The variability of clinical features of UAIM makes the diag...

Authors: Miguel A. de la Fuente and Rubén Cuadrado

Surgical outcomes of uveitic glaucoma

Secondary glaucoma is a difficult and frequent complication of uveitis. The aim of this study is to describe the results of surgery in uveitic glaucoma and to identify situations linked to a high risk of failu...

Authors: Ester Carreño, Sonia Villarón, Alejandro Portero, José M. Herreras, José A. Maquet and Margarita Calonge

Vascular co-option in lung cancer metastatic to the eye after treatment with bevacizumab

Chemotherapy with bevacizumab alters the angiogenic environment, and therefore, the growth and spread of metastases. We present a patient with metastatic lung adenocarcinoma to the eye with findings suggestive...

Authors: Efrem D. Mandelcorn, Alan G. Palestine, Sandor Dubovy and Janet L. Davis

Anterior segment intraocular metallic foreign body causing chronic hypopyon uveitis

Intraocular foreign body (IOFB) is a common association of penetrating ocular trauma. Early diagnosis and removal of IOFBs especially if they are metallic is very important to determine further management and ...

Authors: Güler Mete, Yılmaz Turgut, Arslanhan Osman, Ülkü Gülşen and Artaş Hakan

Isolated uveal tuberculoma masquerading as an intraocular tumor in an immunocompetent patient—a clinical-pathologic study with diagnosis by PCR

The aim of this article is to report a case of uveal tuberculoma simulating an intraocular tumor in which the diagnosis was only possible by polymerase chain reaction (PCR) analysis.

Authors: Eduardo F. Marback, Epaminondas de Souza Mendes Jr, Ricardo D. Chagas Oliveira, Jignesh G. Parikh and Narsing A. Rao

Remembering Professor David BenEzra, M.D., Ph.D., 1942–2008

Authors: Igal Gery and Jorge L. Alio

Diagnosis of tubercular uveitis by quantitative polymerase chain reaction

To report the use of real-time or quantitative polymerase chain reaction (qPCR) in confirming the diagnosis of tubercular uveitis.

Authors: Pooja Sharma, Reema Bansal, Vishali Gupta and Amod Gupta

Journal of Ophthalmic Inflammation and Infection: why a new journal on ocular inflammation?

Authors: Narsing A. Rao

Dark hypopyon in Streptococcus bovis endogenous endophthalmitis: clinicopathologic correlations

The aim of this report is to present a previously unreported causative organism associated with brown-pigmented hypopyon in a patient with endophthalmitis.

Authors: Adam Hauch, Dean Eliott, Narsing A. Rao, Daniel V. Vasconcelos-Santos, Thomas O’Hearn and Amani A. Fawzi

Oxidative photoreceptor cell damage in autoimmune uveitis

Uveitis comprises an extensive array of intraocular inflammatory diseases and often results in irreversible visual loss. Experimental autoimmune uveitis (EAU) is an animal model used to study human uveitis. Bo...

Authors: Angeline M. Nguyen and Narsing A. Rao

Corneal ectasia secondary to peripheral endotheliopathy in a patient with classic pars planitis

To report a case of corneal ectasia secondary to pars planitis corneal endotheliopathy

Authors: Lourdes Arellanes-Garcia, Maricarmen Preciado-Delgadillo, Everardo Hernandez-Quintela and Manuel Garza-Leon