Open Access

Case report: Providencia stuartii conjunctivitis

Journal of Ophthalmic Inflammation and Infection20166:29

https://doi.org/10.1186/s12348-016-0097-9

Received: 29 June 2016

Accepted: 26 July 2016

Published: 16 August 2016

Abstract

Purpose

The purpose of this study is to report a case of Providencia stuartii conjunctivitis.

Methods

This study is a retrospective chart review of a patient with persistent conjunctivitis.

Results

We report the first case of P. stuartii conjunctivitis. Our patient was an elderly man living in a nursing home who was likely immunocompromised from longstanding diabetes mellitus. A conjunctival swab culture was able to identify the infecting bacteria and its antibiotic susceptibility. The conjunctivitis was successfully treated with vancomycin drops and oral sulfamethoxazole and trimethoprim.

Discussion

P. stuartii is an increasingly common bacterium found in the urine of immunocompromised nursing home residents with indwelling Foley catheters. While it has rarely been found to cause ocular infections, P. stuartii may be suspected in elderly, immunocompromised nursing home residents.

Keywords

Bacterial Conjunctivitis Rare Providencia stuartii

Introduction

The genus Providencia includes five facultative gram-negative bacilli, of which Providencia stuartii is the species most commonly causing infection [1]. P. stuartii has been increasingly isolated from urine cultures in nursing home residents with long-term urinary catheters [2]. It is particularly common in patients with blocked indwelling urinary catheters [3] and is also an uncommon cause of bacteremia [1].

Although we could not find any published cases of P. stuartii conjunctivitis, we did find two mentions of P. stuartii keratitis; in both cases, they were listed as one line in a chart of etiologic agents without further comment [4, 5]. Koreishi et al. also detailed five ocular infections by a closely related bacteria, Providencia rettgeri [6].

We report a case of P. stuartii conjunctivitis in an elderly man living in a nursing home in New Jersey.

Case report

A 74-year-old Asian man with diabetes mellitus and glaucoma presented with a 10-month history of worsening vision in his right eye with persistent ocular discharge, pruritus, and irritation. He had an 18-year history of poorly controlled type II diabetes mellitus complicated by end-stage renal disease and diabetic retinopathy. His ophthalmic history included bilateral proliferative diabetic retinopathy (treated with pan-retinal photocoagulation) and bilateral neovascular and chronic angle-closure glaucoma (treated with pressure reduction surgery in his right eye and timolol drops bilaterally). His ophthalmic surgical history included bilateral cataract extraction with posterior chamber intraocular lens (PC IOL) implantation 10 years prior to presentation and two Baerveldt tube insertions in his right eye that were both removed due to hypotony and exposure over 2 years prior to presentation. He has no history of contact lens wear but was a former smoker and is a nursing home resident; he has taken a moxifloxacin hydrochloride table daily since his glaucoma drainage device surgeries. Two years prior to presentation, his visual acuity (VA) was 20/200 in the right eye (RE) and no light perception (NLP) in the left eye (LE).

At presentation, his VA was hand motion in the RE and NLP in the LE. His RE was found to have mucopurulent conjunctivitis (Fig. 1a). The conjunctiva in his LE was clear and quiet. Cultures were taken, and his RE was treated with a betadine wash (in office), vancomycin drops every 2 h, and fortified tobramycin drops every 2 h.
Fig. 1

a RE and b LE anterior segment photographs showing injected and edematous conjunctiva with mucoid discharge

Three weeks later, the patient reported that his RE subjectively improved. On exam, the conjunctiva in his RE was less inflamed but the VA worsened to light perception (LP). Additionally, the conjunctivitis was found to have spread to his LE (Fig. 1b). RE cultures grew P. stuartii susceptible to: piperacillin/tazobactam, ceftazidime, ceftriaxone, cefepime, ertapenem, and trimethoprim/sulfamethoxazole. Cultures were also taken from the LE, which later showed no growth. His vancomycin drops were extended bilaterally, and oral sulfamethoxazole and trimethoprim were started with dose adjusted to his renal clearance. His fortified tobramycin drops were discontinued due to P. stuartii resistance.

Two months after initial presentation, his conjunctivitis had almost completely resolved bilaterally (Fig. 2). His VA remained NLP in his LE, but his RE VA improved to count fingers.
Fig. 2

Anterior segment photograph showing minimal residual conjunctival injection

Discussion

P. stuartii is an increasingly common bacterium found in the urine of nursing home residents with indwelling Foley catheters [2]. In a 12-year study from a large community hospital in Ohio, P. stuartii was found to cause bacteremia in 49 patients [1]. Of these, 78 % were over 70 years of age, 96 % were admitted to the hospital from a nursing home, and 92 % had a long-term indwelling Foley catheter when admitted to the hospital. Our patient was over 70 years old and lived in a nursing home but did not use an indwelling Foley catheter as he had end-stage renal disease.

We could only find two cases of ocular infection due to P. stuartii in the published literature. Both instances were cases of keratitis rather than conjunctivitis, and neither provided detailed information on the individual P. stuartii infection. Sun et al. described P. stuartii keratitis in the right eye of a 13-year-old girl who had worn an orthokeratology lens for 2 years and presented with a corneal ulcer [4]. The textbook, Smolin and Thoft’s The Cornea: Scientific Foundations and Clinical Practice, provides an original chart of gram-negative bacterial isolates from keratitis from Pittsburgh, PA [5]. They found one case of keratitis from P. stuartii that was not susceptible to any of the tested antibiotics.

Koreishi et al. described five ocular infections from a related bacterium, Providencia rettgeri [6]. They detailed two cases of keratitis, one of dacryocystitis, one of conjunctivitis, and one of conjunctivitis/endophthalmitis. All five of their subjects were elderly. Three of their subjects were either locally or systemically immunocompromised (one of their subjects had diabetes and used topical steroids, a second used topical steroids, and a third was being treated with methotrexate). Two of their patients had positive urinary analyses (leukocytosis in one and bacteria in the other), but neither was cultured. They found that concurrent urinary tract infections and an immunocompromised state were likely risk factors.

Similar to other patients infected with P. Stuartii, our patient was an elderly man living in a nursing home who was likely immunocompromised from diabetes mellitus. We could not confirm if his urinary tract was infected with P. stuartii as he produced no urine that could be cultured. Our patient’s conjunctivitis was successfully treated with vancomycin drops, oral sulfamethoxazole and trimethoprim, and oral moxifloxacin hydrochloride. We found that conjunctival swab cultures were instrumental in identifying the infecting bacteria and its antibiotic susceptibility.

In summary, P. stuartii is an uncommon cause of ocular infections, but may be suspected in elderly, immunocompromised nursing home residents.

Abbreviations

LE, left eye; LP, light perception; NLP, no light perception; PC IOL, posterior chamber intraocular lens; RE, right eye; VA, visual acuity

Declarations

Acknowledgements

None.

Funding

None.

Authors’ contributions

ESC and MS contributed to the data collection. ESC, MS, and DSC contributed to the data analysis. DSC interpreted the data. ESC, MS, and DSC wrote the manuscript. ESC and DS critically edited the manuscript. ESC, MS, and DSC approved the final version. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Patient consent was obtained for this publication.

Ethics approval and consent to participate

This project was completed with institutional review board permission and adhered to the Declaration of Helsinki.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors’ Affiliations

(1)
Institute of Ophthalmology and Visual Science, New Jersey Medical School, Rutgers University
(2)
Metropolitan Eye Research and Surgery Institute

References

  1. Woods TD, Watankunakorn C (1996) Bacteremia due to Providencia stuartii: review of 49 episodes. South Med J 89(2):221–224View ArticlePubMedGoogle Scholar
  2. Rahav G et al (1994) Molecular epidemiology of catheter-associated bacteriuria in nursing home patients. J Clin Microbiol 32(4):1031–1034PubMedPubMed CentralGoogle Scholar
  3. Armbruster CE et al (2014) Increased incidence of urolithiasis and bacteremia during proteus mirabilis and Providencia stuartii coinfection due to synergistic induction of urease activity. J Infect Dis 209(10):1524–1532View ArticlePubMedGoogle Scholar
  4. Sun X et al (2006) Infectious keratitis related to orthokeratology. Ophthalmic Physic Opt 26(2):133–136View ArticleGoogle Scholar
  5. Smolin and Thoft’s the cornea: scientific foundations and clinical practice. In: Foster, Charles Stephen, Azar, Dimitri T, Dohlman, Claes H, editors. 4th ed. Philadelphia, PA, USA: Lippincott Williams & Wilkins; 2005.Google Scholar
  6. Koreishi AF, Schechter BA, Karp CL (2006) Ocular infections caused by Providencia rettgeri. Ophthal Eye Dis 113(8):1463–1466View ArticleGoogle Scholar

Copyright

© The Author(s). 2016