Articles

Symptoms and signs of conjunctivitis as predictors of disease course in COVID-19 syndrome

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can induce conjunctivitis signs and symptoms. However, limited information is available on their impact on COVID-19 disease phenotype. Quantificatio...

Authors: Martina Ranzenigo, Elena Bruzzesi, Laura Galli, Antonella Castagna and Giulio Ferrari

Vision-related quality of life and psychosocial well-being of patients with episcleritis and scleritis: a neglected essence?

To assess the change in vision-related quality of life and psychosocial well-being of the patients with episcleritis and scleritis patients before and after treatment.

Authors: Apurva Ratna Tamrakar, Ranju Kharel Sitaula, Sagun Narayan Joshi and Manjita Bajracharya

Effect of SARS-CoV-2 mRNA vaccination on ocular herpes simplex and varicella-zoster virus reactivation: should preventive antiviral treatment be given in known herpes patients

Authors: Carl P. Herbort Jr and Ioannis Papasavvas

Multimodal imaging supporting the pathophysiology of white dot syndromes

White dot syndromes (WDS) represent a heterogeneous group of inflammatory diseases, primarily affecting the outer retina, choriocapillaris and choroid. Recent advances in the field of ocular imaging and develo...

Authors: Ilaria Testi, Rocco Luigi Modugno and Carlos Pavesio

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE)

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare inflammatory eye disease, affecting the inner choroid and the outer retina. Recent advances in multimodal imaging have been importan...

Authors: Ilaria Testi, Sandra Vermeirsch and Carlos Pavesio

Varicella-zoster virus reactivation causing herpes zoster ophthalmicus (HZO) after SARS-CoV-2 vaccination – report of three cases

We are reporting 3 patients who presented acute zoster ophthalmicus (HZO), an activation of varicella-zoster virus, after mRNA anti-SARS-CoV-2 vaccination, seen directly or referred to our center.

Authors: Ioannis Papasavvas, Christian de Courten and Carl P. Herbort Jr

Combined endophthalmitis and orbital cellulitis in patients with corona virus disease (COVID-19)

To document the presentation of unilateral combined endophthalmitis and orbital cellulitis in patients with COVID-19 infection and study their prognosis.

Authors: Mohamed Farouk Sayed Othman Abdelkader, Ahmed Mohamed Kamal Elshafei, Mahmoud Mamdouh Nassar, Mostafa A. Abu Elela and Raafat Mohyeldeen Abdelrahman Abdallah

Fungal keratitis after small incision lenticule extraction (SMILE): a case report and review of the literature

To report a case of perforated fungal keratitis after small incision lenticule extraction (SMILE) treated with penetrating keratoplasty (PKP).

Authors: Mohammad Soleimani and Ali A. Haydar

Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease

Eales’ disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnos...

Authors: Amravi Shah, Sneha Giridhar, Gazal Patnaik, Radhika Mhatre, Dipankar Das, M. K. Janani, Anita Mahadevan and Jyotirmay Biswas

Rituximab for treatment of non-infectious and non-malignant orbital inflammatory disease

To provide a comprehensive review of rituximab use for the treatment of non-infectious/non-malignant orbital inflammation.

Authors: Caleb C. Ng, Aileen Sy and Emmett T. Cunningham Jr

Rituximab for non-infectious Uveitis and Scleritis

To provide a comprehensive review of rituximab use for the treatment of non-infectious uveitis and scleritis.

Authors: Caleb C. Ng, Aileen Sy and Emmett T. Cunningham Jr

Risk factors and outcomes of post-traumatic endophthalmitis: a retrospective single-center study

To describe the epidemiology, characteristics, risk factors, and outcomes of post-traumatic endophthalmitis.

Authors: Nawat Watanachai, Janejit Choovuthayakorn, Susama Chokesuwattanaskul, Chaipot Photcharapongsakul, Praelada Wongsirimeteekul, Phichayut Phinyo, Voraporn Chaikitmongkol, Paradee Kunavisarut, Pongsant Supreeyathitikul and Direk Patikulsila

Effective diagnosis by real-time PCR of herpes simplex diffuse endotheliitis that is similar in appearance to fungal keratitis: case series

Herpes simplex diffuse endotheliitis with accompanying feathery infiltration is difficult to diagnose due to corneal findings that are similar to fungal keratitis. This case series reports on the effectiveness...

Authors: Daisuke Todokoro, Mayumi Hosogai, Satoko Nakano and Hideo Akiyama

Reactivation of Vogt-Koyanagi-Harada disease under control for more than 6 years, following anti-SARS-CoV-2 vaccination

Vogt-Koyanagi-Harada (VKH) disease is a primary stromal choroiditis with bilateral granulomatous panuveitis. If initial-onset VKH is treated early and relentlessly the disease can be controlled and even “cured...

Authors: Ioannis Papasavvas and Carl P. Herbort Jr.

The acute phase response protein SERPINA3 is increased in tear fluid from the unaffected eyes of patients with unilateral acute anterior uveitis

To identify candidate tear fluid biomarkers in patients with unilateral acute anterior uveitis (AAU) that can aid in the differentiation between these patients and patients with bacterial keratitis or healthy ...

Authors: Jon Roger Eidet, Maja Akopian, Ole K. Olstad, Øystein Kalsnes Jørstad, Morten C. Moe, Goran Petrovski and Milaim Pepaj

Foveal reorganization after treatment of acute foveal toxoplasmic retinochoroiditis

To report a patient with impaired vision due to foveal involvement of toxoplasmic retinochoroiditis, who was successfully treated with intravitreal clindamycin and dexamethasone and oral therapy with azithromy...

Authors: Mojtaba Abrishami, Seyedeh Maryam Hosseini, Solmaz Momtahen and Ghodsieh Zamani

Factors associated with the development of ocular candidiasis and ocular prognosis with echinocandin therapy for candidemia

To evaluate the factors associated with the development of ocular candidiasis (OC) and ocular prognosis with echinocandin therapy for candidemia.

Authors: Daiki Sakai, Wataru Matsumiya, Sentaro Kusuhara and Makoto Nakamura

Post-traumatic exogenous endophthalmitis caused by Nocardia farcinica

A case report of post-traumatic exogenous endophthalmitis caused by Nocardia farcinica, including treatment procedures, microbiology examination, and systemic medications. A 23-year-old male suffered a penetratin...

Authors: Marie Česká Burdová, Kateřina Donátová, Gabriela Mahelková, Vanda Chrenková and Dagmar Dotřelová

“Environmental risk factors associated with juvenile idiopathic arthritis associated uveitis: a systematic review of the literature”

Juvenile idiopathic arthritis associated uveitis (JIA-U) is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA) and carries considerable risk to vision. The aim of this systema...

Authors: Sarah L. N. Clarke, Katie S. Mageean, Henry Carlton, Gabriele Simonini, Gemma C. Sharp, Caroline L. Relton and Athimalaipet V. Ramanan

“Old wine in a new bottle” - post COVID-19 infection, central serous chorioretinopathy and the steroids

Corona virus disease (COVID-19) pandemic can cause myriad of ocular manifestations.

Authors: Srinivasan Sanjay, Poornachandra B. Gowda, Bhimasena Rao, Deepashri Mutalik, Padmamalini Mahendradas, Ankush Kawali and Rohit Shetty

Varicella zoster virus anterior uveitis complicated by thalamic stroke

We report a case of varicella zoster virus (VZV)-associated anterior uveitis in a patient with weight loss, arthritis and signs of inflammatory bowel disease. Her clinical course included the development of a ...

Authors: Casey L. Anthony, Anastasios P. Costarides, Steven Yeh and Jessica G. Shantha

Clinical course, treatment and visual outcome of an outbreak of Burkholderia contaminans endophthalmitis following cataract surgery

Postoperative endophthalmitis is a rare but dreaded complication of intraocular surgery and often results in severe visual impairment or blindness. The present study describes the clinical course, treatment an...

Authors: Caroline Lind, Karina Olsen, Nina K. Angelsen, Einar A. Krefting, Kristian Fossen, Kirsten Gravningen, Eliza Depoorter, Peter Vandamme and Geir Bertelsen

Current concepts in the diagnosis and management of antiphospholipid syndrome and ocular manifestations

Antiphospholipid syndrome (APS) is an autoimmune disorder associated with obstetrical complications, thrombotic complications involving both arteries and veins, and non-thrombotic manifestations affecting mult...

Authors: Gunay Uludag, Neil Onghanseng, Anh N. T. Tran, Muhammad Hassan, Muhammad Sohail Halim, Yasir J. Sepah, Diana V. Do and Quan Dong Nguyen

Central retinal vein occlusion in the setting of COVID-19 infection

Authors: Nilesh Raval, Anna Djougarian and James Lin

Abducens nerve palsy with associated retinal involvement secondary to rickettsia typhi infection

To report a case of abducens nerve palsy with associated retinal involvement due to rickettsia typhi infection.

Authors: Kaies Abderrahim, Sourour Zina, Molka Khairallah, Hager Ben Amor, Sana Khochtali and Moncef Khairallah

Clinical outcomes of pediatric macular edema associated with non-infectious uveitis

Macular edema (ME) is the most frequent cause of irreversible visual impairment in patients with uveitis. To date, little data exists about the clinical course of ME in pediatric patients. A retrospective, obs...

Authors: Anh Hong Nguyen, Bethlehem Mekonnen, Eric Kim and Nisha R. Acharya

Common bacterial causes of external ocular infections, associated risk factors and antibiotic resistance among patients at ophthalmology unit of Felege Hiwot Referral Hospital, Northwest Ethiopia: a cross-sectional study

Ocular infections are a serious public health problem in Ethiopia with increased incidence of morbidity and blindness. Empirical therapy with topical ophthalmic broad spectrum antibiotic formulations is also a...

Authors: Zimam Ayehubizu, Wondemagegn Mulu and Fantahun Biadglegne

Persumed sympathetic Ophthalmia after scleral buckling surgery: case report

Scleral buckling (SB) is usually considered an extraocular operation premeditated to have a low risk of sympathetic ophthalmia (SO). Here we report a rare case of presumed SO in a young female patient followin...

Authors: Seyedeh Maryam Hosseini, Nasser Shoeibi, Mahdieh Azimi Zadeh, Mahdi Ghasemi and Mojtaba Abrishami

Serum IgE reduction and paradoxical eosinophilia associated with allergic conjunctivitis after dupilumab therapy

Authors: Ayaka Kimura, Ayaka Takeda, Toyo Ikebukuro and Junko Hori

Vogt-Koyanagi-Harada disease is always bilateral: reports of unilateral cases failed to use choroidal investigations showing subclinical involvement of the fellow eye

Vogt-Koyanagi-Harada (VKH) disease is a primary stromal choroiditis and a bilateral granulomatous panuveitis which, if not treated early and properly, could have a deleterious evolution. The purpose of our cas...

Authors: Ioannis Papasavvas and Carl P. Herbort Jr

Subacute Sclerosing Panencephalitis manifesting as Bell’s palsy and bilateral macular necrotizing retinitis: an atypical presenting feature

Subacute sclerosing panencephalitis (SSPE) is a potentially lethal complication of measles infection. Neurological complications take years to manifest after primary viral infection of brain and can lead to bl...

Authors: Lagan Paul, Tanya Jain, Manisha Agarwal and Shalini Singh

Peripheral retinal arteriolar leakage in giant cell arteritis: a case report

A 76-year old African American female with a history of arteritic ischemic optic neuropathy (AION) secondary to biopsy-proven giant cell arteritis (GCA) presented with unilateral vision loss in her contralater...

Authors: Meleha Ahmad, Andrew R. Carey, Charles G. Eberhart, Sepideh Siadati and Amanda D. Henderson

Intravenous administration of Penicillin results in therapeutic intravitreal levels in chronic postoperative endophthalmitis

The role of systemic antibiotics in the treatment of bacterial endophthalmitis remains controversial. While penicillin is a highly effective antibiotic against bacteria that frequently cause endophthalmitis, t...

Authors: Chloe Thabet, Chloe C. C. Gottlieb, Bernard R. Hurley, Guijun Zhang, Adeel Sherazi and Jonathan B. Angel

Acute macular neuroretinopathy in a patient with acute myeloid leukemia and deceased by COVID-19: a case report

Acute macular neuroretinopathy (AMN) is a visual-deteriorating rare clinical entity with an uncertain etiology. We aimed to report a case of AMN and underlying disease of acute myeloid leukemia (AML).

Authors: Ghodsieh Zamani, Sajjad Ataei Azimi;, Ali Aminizadeh, Elham Shams Abadi, Mostafa Kamandi, Hasan Mortazi, Somayeh Shariat and Mojtaba Abrishami

Drug-induced ectropion following the chronic use of topical Natamycin

Authors: Mohammad Soleimani, Farzad Pakdel and Mohammad Mehrpour

Cytokine profiles in the peripheral blood and aqueous humor of patients with herpetic uveitis

Authors: Marta Catarina Esteves Guedes, Catarina Gregório Martins, Maria Jorge Arroz, Miguel Angelo-Dias, Luís Miguel Borrego and Rui Daniel Proença

Comparison of fundus fluorescein angiography, optical coherence tomography and optical coherence tomography angiography features of macular changes in Eales disease: a case series

To study the macular features in Eales disease patients observed with fundus fluorescein angiography (FA), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).

Authors: Ketaki Rajurkar, Meenakshi Thakar, Priyadarshi Gupta and Anju Rastogi

Sequential bilateral Behçet’s neuroretinitis associated with prepapillary vitreous exudate: case report

To describe a case of Behçet disease (BD) uveitis manifesting with sequential bilateral neuroretinitis associated with prepapillary inflammatory vitreous exudate (PIVE).

Authors: Imen Ksiaa, Safa Ben Aoun, Sourour Zina, Dhouha Nefzi, Sana Khochtali and Moncef Khairallah

Current diagnostic tools and management modalities of Nocardia keratitis

Nocardia species are an uncommon but important cause of keratitis. The purpose of this review is to discus previous published papers relation to the epidemiology, etiology, diagnosis and management of Nocardia ke...

Authors: Mohammad Soleimani, Ahmad Masoumi, Sadegh Khodavaisy, Mostafa Heidari, Ali A. Haydar and Alireza Izadi

Preventing relapse in non-infectious uveitis affecting the posterior segment of the eye – evaluating the 0.2 μg/day fluocinolone acetonide intravitreal implant (ILUVIEN^®)

The current article is a short review of an Alimera Sciences-sponsored symposium held during The 15th International Ocular Inflammation Society Congress in Taiwan on the 14th November 2019 entitled, ‘Preventing r...

Authors: Bahram Bodaghi, Quan Dong Nguyen, Glenn Jaffe, Ramin Khoramnia and Carlos Pavesio

A ten-year report of microbial keratitis in pediatric population under five years in a tertiary eye center

To report characteristics of microbial keratitis in pediatric patients under five years.

Authors: Mohammad Soleimani, Seyed Ali Tabatabaei, S. Saeed Mohammadi, Niloufar Valipour and Arash Mirzaei

The clinical spectrum of ocular bartonellosis: a retrospective study at a tertiary centre in Malaysia

Cat scratch disease (CSD) is a systemic illness caused by the gram-negative bacillus, Bartonella henselea, which can occasionally involve the ocular structures. The objective of this study is to evaluate the vari...

Authors: Michele Shi-Ying Tey, Gayathri Govindasamy and Francesca Martina Vendargon

Increased incidence of glaucoma medication usage in middle-aged Australian males taking antiretroviral medication – a population-based study

To investigate a possible association between glaucoma and the use of anti-retroviral therapy (ART) for HIV in the Australian population.

Authors: Wen-Shen Lee, Shaun Parsons, Dean Cugley, Sophie Rogers, Lyndell L. Lim and Anthony Hall

Occlusive retinal vasculitis and periphlebitis in Buerger’s disease: a case report

Authors: Ioannis S. Dimopoulos, Michael Dollin and Chloe C. Gottlieb

Ocular syphilis with optic disc neovascularization treated with bevacizumab evaluated by OCT angiography and electroretinography

We present our findings in an atypical case of ocular syphilis with optic disc neovascularization that was treated with intravitreal bevacizumab and followed by multimodal imaging and electroretinography. A 29...

Authors: Gen Miura, Takayuki Baba, Marie Takeishi, Tomoaki Tatsumi, Hirotaka Yokouchi and Shuichi Yamamoto

Susac syndrome (Retino-cochleo-cerebral vasculitis), the ophthalmologist in the role of the whistleblower

Susac syndrome is a rare microangiopathy of suspected autoimmune origin affecting arteries of the retina, the cochlea and the brain. The aim of the study was to give a review of the disease entity and determin...

Authors: Ioannis Papasavvas, Barbara Teuchner and Carl Peter Herbort Jr

Multiple evanescent white dot syndrome and panuveitis: a case report

To report a patient with multiple evanescent white dot syndrome (MEWDS) complicated by iridocyclitis and vitritis.

Authors: Kazuomi Mizuuchi, Wataru Saito, Kenichi Namba and Susumu Ishida

Characterization of Pseudomonas aeruginosa isolates from patients with endophthalmitis using conventional microbiologic techniques and whole genome sequencing

To demonstrate antibiotic susceptibility and genomic virulence factor profiles of Pseudomonas aeruginosa isolates from patients with culture-confirmed endophthalmitis.

Authors: Jesse D. Sengillo, Jacob Duker, Maribel Hernandez, Jorge Maestre, Daniela Reyes-Capo, Annika Patel, Arjun Watane, Nimesh A. Patel, Nicolas A. Yannuzzi, Darlene Miller and Harry W. Flynn Jr

Incidence of uveitis and macular edema among patients taking fingolimod 0.5 mg for multiple sclerosis

Patients with multiple sclerosis (MS) have a higher incidence of uveitis compared with the general population. Fingolimod, a first line disease modifying drug used in multiple sclerosis, may cause macular edem...

Authors: Scott Joseph Sonne and Bradley Thomas Smith

Initial-onset acute and chronic recurrent stages are two distinctive courses of Vogt-Koyanagi-Harada disease

To describe distinctive stages of Vogt-Koyanagi-Harada (VKH) disease: initial-onset acute versus chronic recurrent disease.

Authors: Cristhian A. Urzua, Carl Herbort Jr, Rodrigo A. Valenzuela, Ahmed M. Abu El-Asrar, Lourdes Arellanes-Garcia, Ariel Schlaen, Joyce Yamamoto and Carlos Pavesio