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Table 1 Previous case reports of post-SMILE infectious keratitis

From: Fungal keratitis after small incision lenticule extraction (SMILE): a case report and review of the literature

Author

Age/Sex

Onset

Pathogen

Characteristic of infiltrates

Management

Outcome (BCVA)

Chehaibou 20164

39/M

Day 2

S. pneumoniae

OU: multiple white, at the cap

• Interface wash: povidone-iodine, vancomycin

• Fortified antibiotics drops: ticarcillin, gentamicin, and vancomycin

At 3-month

OD: CF 50 cm → 20/32

OS: HM → 20/25

Chan 20173

18/F

Day 5

S. haemolyticus and warneri

OD: paracentral, anterior cap

• PACK-CXL

• Fortified antibiotics drops: vancomycin, gentamicin

At 2-week

OD: 20/50 → 20/20

Liu 20187

21/F

Day 8

M. abscessus

OD: multiple, paracentral, within the cap

OS: temporal interface

• Interface wash: moxifloxacin

• Fortified antibiotics drops: imipenem, amikacin, moxifloxacin, clarithromycin

• Oral clarithromycin

At 4-month

OD: 20/32 → 20/32

OS: 20/132 → 20/50

Sachdev 20198

20/F

Day 1

Aspergillus species

OD: focal, paracentral, involving the interface

• Interface wash: voriconazole

• Fortified antifungals drops: voriconazole and natamycin

At 3-month

OD: 20/45

Ganesh 20205

42/F

Day 2

Staphylococcus

aureus

OS: superficial, mid-periphery

• PACK-CXL

• Interface wash: vancomycin, moxifloxacin

• Fortified antibiotics drops: vancomycin, cefotaxime

At 3-month

OS: 20/20

  1. SMILE: small incision lenticule extraction; M: male; F: female; OU: both eyes; OD: right eye; OS: left eye; BCVA: best-corrected visual acuity; CF: counting fingers; HM: hand motion; PACK-CXL: collagen cross-linking with photoactivated riboflavin