- Brief report
- Open Access
Bilateral nongranulomatous anterior uveitis associated with chancre of the tongue: initial presentation of syphilis
© Freitas-Neto et al.; licensee Springer. 2013
- Received: 19 November 2012
- Accepted: 25 January 2013
- Published: 11 February 2013
This paper reports the case of a pleomorphic manifestation of syphilis, a reemerging sexually transmitted disease.
A 51-year-old male presented with bilateral nongranulomatous anterior uveitis associated with an isolated syphilitic chancre of the tongue that was successfully treated with parenteral benzathine penicillin.
Syphilis has the potential to lead to any type of intraocular inflammation. A careful review of the symptoms is useful for the detection of extraocular signs of syphilitic infection.
- Ocular syphilis
- Anterior uveitis
- Tongue chancre
- Case reports
Data from the World Health Organization indicate an increase in the incidence of syphilis, with an estimated 12 million new cases per year worldwide, particularly involving co-infection with human immunodeficiency virus (HIV) . Ophthalmologists have the opportunity to diagnose and perform early treatment of this reemerging disease [2–4].
Ocular manifestations are reported in only 14% of immunocompetent individuals with syphilis. In those with HIV co-infection, however, this rate reaches 36% . Posterior uveitis is the most common manifestation of syphilitic intraocular inflammation . While serological tests are required to arrive at a definitive diagnosis, the recognition of other systemic signs of syphilis may also be helpful.
This paper describes a case of bilateral nongranulomatous anterior uveitis associated with a syphilitic chancre of the tongue.
The patient’s best-corrected visual acuity was 20/32 in the right eye and 20/25 in the left eye. Slit lamp examination revealed sparse fine keratic precipitates in both eyes, 2+ cells, and flare in the anterior chamber of the right eye and trace cells in the left eye. Dilated bilateral fundus examination was normal. Applanation tonometry revealed intraocular pressure of 26 mmHg in the right eye and 27 mmHg in the left.
The patient was submitted to a systemic workup, including complete blood count and screening tests for HIV, syphilis, and tuberculosis. Computer-assisted tomography of the head and a chest X-ray were also performed. All results were negative, except the syphilis serology, which revealed a positive venereal disease research laboratory (VDRL) test (titer of 1:128) and Treponema pallidum hemagglutination test. Lumbar puncture was recommended but could not be performed.
Syphilis is well known for its diversity of ocular and extraocular manifestations. Although oral ulcers have been widely recognized as possibly related to syphilitic infection, the occurrence of lesions consistent with an oral syphilitic chancre has not yet been clearly associated with intraocular inflammation [7–9]. Such lesions may be overlooked, as they are generally associated with primary syphilis and may spontaneously resolve before the development of ocular disease. Moreover, these lesions are not typically painful  and ophthalmologists do not routinely perform an examination of the oral cavity.
As no cerebrospinal fluid analysis could be performed in the present case, the patient received treatment for neurosyphilis despite the absence of retinal/optic nerve involvement, with the subsequent resolution of intraocular inflammation and healing of the tongue chancre.
In view of the increasing incidence of syphilis, its association with HIV infection, and the variety of clinical manifestations, this sexually transmitted disease should be considered even in the setting of apparently innocent nongranulomatous anterior uveitis. Supportive systemic findings, which may include syphilitic chancre, should be investigated and are easily detected upon careful examination.
Written informed consent was obtained from the patient for publication of this report and accompanying images. This work was performed with the approval of the Department of Ophthalmology of the Hospital das Clínicas de Minas Gerais (Brazil), according to the tenets of the declaration of Helsinki.
- Hook EW, Peeling RW: Syphilis control - a continuing challenge. N Engl J Med 2004, 351: 122–124. 10.1056/NEJMp048126PubMedView ArticleGoogle Scholar
- Chao JR, Khurana RN, Fawzi AA, Reddy HS, Rao NA: Syphilis: reemergence of an old adversary. Ophthalmology 2006, 113: 2074–2079. 10.1016/j.ophtha.2006.05.048PubMedView ArticleGoogle Scholar
- Hong MC, Sheu SJ, Wu TT, Chuang CT: Ocular uveitis as the initial presentation of syphilis. J Chin Med Assoc 2007,70(7):274–280. 10.1016/S1726-4901(07)70004-7PubMedView ArticleGoogle Scholar
- Workowski KA, Berman S, Centers for Disease Control and Prevention (CDC) (2010): Sexually transmitted diseases treatment guidelines. Morbidity and Mortality Weekly Report: Recommendations and Reports 2010,59(RR-12):26–44.Google Scholar
- Katz DA, Berger JR, Duncan RC: Neurosyphilis: a comparative study of the effects of infection with immunodefficiency virus. Arch Neurol 1993,50(3):243–249. 10.1001/archneur.1993.00540030009006PubMedView ArticleGoogle Scholar
- Amaratunge BC, Camuglia JE, Hall AJ: Syphilitic uveitis: a review of clinical manifestations and treatment outcomes of syphilitic uveitis in human immunodeficiency virus-positive and negative patients. Clin Experiment Ophthalmol 2010,38(1):68–74. 10.1111/j.1442-9071.2010.02203.xPubMedView ArticleGoogle Scholar
- Lu SY, Eng HL: Secondary syphilis-related oral ulcers: report of four cases. Chang Gung Med J 2002,25(10):683–688.PubMedGoogle Scholar
- Staines K, Sloan P: Images in clinical medicine. Syphilitic chancre of the tongue. N Engl J Med 2011,365(5):e 11.View ArticleGoogle Scholar
- Leuci S, Martina S, Adamo D, Ruoppo E, Santarelli A, Sorrentino R, Flavia G, Mignogna M: Oral syphilis: a retrospective analysis of 12 cases and a review of the literature. Oral Dis 2012. 10.1111/odi.12058Google Scholar
- Dalmau J, Alegre M, Sambeat MA, Roé E, Peramiquel L, Alomar A: Syphilitic nodules on the tongue. J Am Acad Dermatol 2006,54(2 Suppl):S59-S60.PubMedView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.