Presumed occult globe rupture resulting in sympathetic ophthalmia
© The Author(s) 2011
Received: 29 July 2011
Accepted: 5 December 2011
Published: 27 December 2011
Sympathetic ophthalmia (SO) is an uncommon bilateral granulomatous panuveitis following uveal trauma to one eye. We present an unusual case of SO which resulted from presumed occult globe rupture following blunt trauma; and highlight the association of trauma and acquired external ocular pigmentation as a possible predictor for SO.
Five weeks following blunt trauma to the left eye (OS), a 30-year-old patient presented complaining of spontaneous blurred vision (4/60) in the right eye (OD). In the OD, there was anterior chamber and vitreous inflammation (3+), multiple areas of serous retinal detachments, Dalen Fuchs spots, and optic disk swelling. In the OS, there was iridodialysis, post-traumatic acquired external ocular pigmentation suggestive of occult globe rupture.
This was diagnosed as SO and treated with systemic steroids and a steroid sparing agent; which resulted in resolution of the inflammation with improvement in the visual acuity.
Sympathetic ophthalmia has been reported to occur following penetrating eye injury secondary to trauma and surgery, and also secondary to non-penetrating eye trauma. This case reports SO occurring after presumed occult globe rupture; and reinforces the association between acquired external ocular pigmentation and SO in the context of trauma.
Sympathetic ophthalmia (SO) is an uncommon bilateral granulomatous panuveitis following uveal trauma to one eye. The British Ophthalmology Surveillance Unit (BOSU) reported an incidence of SO of 0.03 per 100,000 .
We present an unusual case of SO which resulted from a presumed occult globe rupture following blunt trauma; and highlight the fact that acquired external ocular pigmentation in association with trauma can be a possible predictor for SO.
A diagnosis of sympathetic ophthalmia following presumed occult globe rupture was made. Other possible causes were considered including sarcoidosis, syphilis, and Vogt Koyanagi Harada syndrome (VKH). The patient did not give a history of respiratory problems. Serum calcium and ACE levels were within normal limits. Treponema serology was negative. With regards to VKH, the patient was a Caucasian and did not manifest any features of neurological deficit, alopecia, or poliosis. Furthermore, the occurrence of the ocular signs and symptoms in such close proximity to the history of trauma favored a diagnosis of SO.
The patient was admitted to hospital for pulsed intravenous methylprednisolone 1 g daily for 3 days. The patient’s vision improved to 6/6 bilaterally with the steroids. The inflammation subsided and the serous RDs improved (Fig. 2b, d). He was eventually discharged from the eye ward on 60 mg oral prednisolone and tacrolimus 1 mg BD. One month following discharge, the patient was still doing well with stable visual acuities.
However, during the subsequent visit (4 weeks later), it was noted that compliance with treatment was sub-optimal due to the social circumstances of the patient. This was reflected in diminishing visual acuities in both eyes (OD 6/24; OS 2/60) and reactivation of the bilateral granulomatous panuveitis. Attempts to re-admit the patient to hospital were declined. The patient has failed to attend all further follow-up reviews. This therefore limited the length of follow-up period to just 2 months post discharge from hospital.
Our case describes SO in a context suggestive of a self-sealing and occult globe rupture. Predictors of scleral rupture including a significantly reduced visual acuity, low intraocular pressure, and relative afferent pupillary defect were absent during the patient’s initial presentation .
The sub-conjunctival pigmentation superiorly and nasally in the left eye was consistent with acquired external ocular pigmentation. Such findings have been reported in the literature in association with globe rupture [3, 4].
Moreover, significant sub-conjunctival pigmentation has also been reported to be associated with SO in relation to pars plana vitrectomy . The histopathological findings are those of deposition of melanin granules both extracellularly and within macrophages .
The combination of trauma, sub-conjunctival pigmentation, and onset of SO reinforces our suspicion of a presumed self-sealing and occult globe rupture. We postulate that hypotony was never present at the initial presentation and follow-up reviews because the presumed rupture was self-sealing and hence precluding a low IOP.
The temporal association between the injury sustained to the left eye and resultant bilateral intraocular inflammation would suggest trauma as the precipitant factor. We therefore suggest that SO is the pathogenic process in this patient.
This case demonstrates that it is likely that SO can occur following occult globe rupture as well; and highlights the fact that acquired external ocular pigmentation in association with trauma can be a possible predictor for SO.
Iain Smith, John McCormick Medical Photography Tennent Institute of Ophthalmology 1053, Great Western Road, Glasgow, UK.
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