- Brief Report
- Open Access
Kyrieleis plaques in cytomegalovirus retinitis
© The Author(s) 2011
- Received: 24 April 2011
- Accepted: 17 July 2011
- Published: 12 August 2011
The purpose of this study is to report a case of Kyrieleis plaques (segmental retinal periarteritis) associated with cytomegalovirus (CMV) retinitis.
A 47-year-old female with recently diagnosed human immunodeficiency virus and a CD4 count of 55 cells/µl presented with decreased vision and floaters in her left eye. Ophthalmic examination revealed an advancing border of white granular CMV retinitis extending into the macula. Intraocular aqueous specimen contained 420,000 copies/ml of CMV DNA by polymerase chain reaction. The patient was treated with intravitreal foscarnet and oral valganciclovir.
Kyrieleis plaques involving the retinal arteries were noted on presentation and increased during the first 6 weeks of treatment as the retinitis faded. The plaques on fluorescein angiography did not leak fluorescein dye and slowly faded over 5 months.
Kyrieleis plaques can be seen in the setting of CMV retinitis. These plaques can be differentiated from vascular sheathing and frosted branch angiitis by its occurrence only in the retinal arteries and the absence of leakage of fluorescein dye.
- Kyrieleis plaque
- Segmental periarteritis
Kyrieleis plaques, also referred to as segmental retinal periarteritis, were first described in an eye with tuberculosis uveitis by Kyrieleis in 1933 . In 1959, Griffin and Bodian used the term segmental retinal periarteritis to describe them . These plaques appear as whitish, segmented deposits found within the walls of the retinal arteries. Kyrieleis plaques have been primarily described in association with infections of the retina, Toxoplasma gondii chorioretinitis being the most common. They have also been reported with Rickettsia conorii, Mycobacterium tuberculosis, Treponema pallidum, and varicella-zoster virus (VZV) infections [1, 3–7].
The etiology of Kyrieleis plaques has not been well established. Orzalesi and Ricciardi suggested these lesions are an immune response to an infectious agent and result from the deposition of immune cells and inflammatory debris in the arterial walls . Others have debated this hypothesis since these plaques can persist despite resolution of the infection and treatment with steroids . Wise suggested these plaques represented arteriosclerosis, while others have postulated they resulted from migration of exudates from active choroiditis to periarterial sheaths where anatomical variation leads to compartmentalization of the exudates [2, 9]. No histopathological evaluation of these plaques has been performed.
The purpose of our report is to describe the presence of Kyrieleis plaques, distinct from vascular sheathing and frosted branch angiitis, associated with cytomegalovirus (CMV) retinitis. To our knowledge, this association appears to be rarely acknowledged and not previously reported.
Laboratory evaluation revealed an elevated serum CMV IgG antibody with a negative systemic work up for T. gondii, VZV, herpes simplex virus (HSV), T. pallidum, and tuberculosis. CD4 T cell count was 55 cells/μL, and HIV viral load was 193,065 copies/ml. Polymerase chain reaction of the aqueous was positive for CMV DNA (420,000 copies/ml) and negative for HSV and T. gondii DNA.
CMV retinitis typically presents with focal areas of retinal necrosis with primary lesions usually located adjacent to blood vessels, secondary to hematogenous spread of the virus . On funduscopic examination, the appearance of CMV retinitis can range from a dry-appearing irregular and granular border with satellite lesions to an edematous and confluent area of thick, yellow-white necrosis associated with retinal hemorrhages and vascular sheathing .
Vascular involvement in CMV retinitis can result in vascular sheathing. Exudates around retinal vessels, more commonly veins, can result in focal areas of fluffy white cuffing or sheathing, with or without skip areas . When the perivascular sheathing is severe, the retinal arteries and veins appear frosted, and the term “frosted branch angiitis” is used to describe this entity . Kyrieleis plaques can be differentiated from vascular sheathing and frosted branch angiitis by its clinical and fluorescein angiographic features. Kyrieleis plaques affect only the retinal arteries in contrast to frosted branch angiitis that involves both the retinal arteries and veins. In addition, Kyrieleis plaques are confined to the vessel wall and do not leak fluorescein dye in contrast to frosted branch angiitis that extends outside the vessel wall and extensively leaks fluorescein dye [12, 13].
Kyrieleis plaques have been primarily reported in association with toxoplasmosis chorioretinitis. Although the cause of Kyrieleis plaques is unclear, the increase in these plaques following treatment and immune recovery in our case supports the theory of an immune response to an infectious agent and deposition of inflammatory debris as the etiology of these plaques. Kyrieleis plaques, although not specifically noted in many reports of infectious chorioretinitis, may be under reported. While many authors have concluded that Kyrieleis plaques are rare, Griffin and Bodian in 1959 felt that they may be more common than the literature suggests . We have found at least one case of CMV retinitis in the literature that appears to also have had Kyrieleis plaques, similar to our patient . Our case adds CMV retinitis to the list of causes of Kyrieleis plaques.
This study was supported in part by the Department of Ophthalmology Research Fund and the Norma Lazar Eye Research Grant of The New York Eye & Ear Infirmary.
- Kyrieleis W (1933) Uber atypische gerfaesstuberkulose der netzhaut. Arch Augenheilkd 107:182–190Google Scholar
- Griffin AO, Bodian M (1959) Segmental retinal periarteritis; a report of three cases. Am J Ophthalmol 47:544–548PubMedView ArticleGoogle Scholar
- Frances-Munoz E, Gallego-Pinazo R, Lopez-Lizcano R et al (2010) Kyrieleis vasculitis in acute retinal necrosis. Clin Ophthalmol 4:837–838PubMedPubMed CentralGoogle Scholar
- Schwartz PL (1977) Segmental retinal periarteritis as a complication of toxoplasmosis. Ann Ophthalmol 9:157–162PubMedGoogle Scholar
- Khairallah M, Ladjimi A, Chakroun M et al (2004) Posterior segment manifestations of Rickettsia conorii infection. Ophthalmol 111:529–534View ArticleGoogle Scholar
- Krishnamurthy R, Cunningham ET Jr (2008) Atypical presentation of syphilitic uveitis associated with Kyrieleis plaques. Br J Ophthalmol 92:1152–1153PubMedView ArticleGoogle Scholar
- Brown RM, Mendis U (1973) Retinal arteritis complicating herpes zoster ophthalmicus. Br J Ophthalmol 57:344–346PubMedPubMed CentralView ArticleGoogle Scholar
- Orzalesi N, Ricciardi L (1971) Segmental retinal periarteritis. Am J Ophthalmol 72:55–59PubMedView ArticleGoogle Scholar
- Wise GN (1961) Uveitis with secondary retinal arteriosclerosis. Am J Ophthalmol 51:797–807PubMedView ArticleGoogle Scholar
- Vaudaux JD, Holland GN (2006) Cytomegalovirus infections of the retina. In: Ryan SJ, Schachat AP, Wilkinson CP et al (eds) Retina, 4th edn. Elsevier, Philadelphia, pp 1605–1623View ArticleGoogle Scholar
- El-Asrar AM, Herbort CP, Tabbara KF (2010) A clinical approach to the diagnosis of retinal vasculitis. Int Ophthalmol 30:149–173PubMedView ArticleGoogle Scholar
- Walker S, Iguchi A, Jones NP (2004) Frosted branch angiitis: a review. Eye 18:527–533PubMedView ArticleGoogle Scholar
- Walton RC, Ashmore ED (2003) Retinal vasculitis. Curr Opin Ophthalmol 14:413–419PubMedView ArticleGoogle Scholar
- Babu K, Murthy KR, Sudarshan S et al (2010) Bilateral arteritis with cytomegalovirus retinitis in a patient infected with human immunodeficiency virus. Retin Cases Brief Rep 4:31–33PubMedView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.