- Brief Report
- Open Access
Rituximab in refractory Vogt–Koyanagi–Harada disease
© The Author(s) 2011
- Received: 17 June 2011
- Accepted: 24 June 2011
- Published: 9 July 2011
Vogt–Koyanagi–Harada (VKH) prognosis depends on early recognition and treatment; chronic disease may be developed when either delayed or inadequate treatment is performed, whereas other cases despite correct treatment are refractory to different drugs and also become chronic. We report a case of refractory VKH controlled with rituximab treatment.
A 41-year-old female with painful visual loss and headache was examined. (VA 0.4 in RE and hand movements (HM) in LE). Retinal examination demonstrated multiple serous retinal detachments in both eyes. High-dose oral steroids were started, followed by progressive tapering of prednisone. New acute anterior and posterior relapses were achieved, and other immunommodulators were progressively added—new high-dose steroid treatment, adalimumab, cyclosporine, and methotrexate—but patient had new anterior and posterior recurrences associated with tinnitus and headache. Thus, an infusion of 1 g of rituximab was administered after 15 months follow-up; the VA was 0.2 in RE and counting fingers in LE. Three additional doses of 1 g each were administered 1, 6, and 16 months later. We have achieved a final VA after 34 months follow-up of 0.2 in RE and HM in LE, with definitive control of inflammation, without acute relapses since rituximab was administered.
After searching PubMed/Medline, this is the first report of VKH disease treated with rituximab. Additional studies are warranted to confirm the efficacy of this new approach for inflammatory control in refractory cases of VKH disease.
- Chronic VKH
Vogt–Koyanagi–Harada (VKH) disease is a T-cell mediated autoimmune disorder with an acute phase of severe bilateral panuveitis and exudative retinal detachment. Patients adequately treated with high-dose systemic corticosteroids at the onset of the disease frequently have rapid resolution of inflammation with good visual outcome . However, more than half of these patients, particularly those who receive either delayed or inadequate treatment, may develop chronic disease with consequent poor visual prognosis due to cataract, glaucoma, subretinal fibrosis, choroidal neovascularization, or choroidal atrophy . These complications are accompanied by alterations in the retinal pigment epithelium in the form of hypo or hyperplasia or granular changes leading to a sunset glow appearance associated in some cases with Dalen-Fuchs nodules . Thus, to prevent recurrences or to control these when chronic disease is developed, in non-responsive patients or when corticosteroid side effects are not well tolerated, other immunomodulatory agents may be needed (corticosteroid-saving agents) .
Rituximab is a human–murine chimeric monoclonal antibody targeting CD20, a transmembrane protein present on immature and mature B cells. It was first approved for the treatment of non-Hodgkin's B-cell lymphoma, and it is very effective for depleting both normal and malignant CD20 B cells in vivo. There are only a few publications about the efficacy and tolerability of rituximab treatment in patients with autoimmune ocular inflammatory diseases. It has been used in cases of refractory endogenous anterior uveitis and Wegener's granulomatosis associated with peripheral ulcerative keratitis [5, 6]. Other uses in ophthalmology have been reported, such as corticosteroid-resistant thyroid-associated ophthalmopathy or in patients with juvenile idiopathic arthritis-associated uveitis [7, 8].
In an automatic search in PubMed/Medline, we did not find any report about the use of rituximab for either acute or chronic VKH.
A 41-year-old Caucasian female from Argentina attended to our department complaining of bilateral painful visual loss, associated with headache and tinnitus.
VKH prognosis depends on early recognition and aggressive suppression of inflammation. The use of high-dose steroids and other immunosuppressant agents has improved significantly the visual outcome ; however, VKH may be a disease difficult to treat with chronic relapses and may require the use of other immunosuppressive drugs like TNF blockers (infliximab or adalimumab) [10, 11] or different combination therapy . Intravitreal treatments with steroids and vascular endothelial growth factor inhibitors have been also reported as adjuvant possibilities with variable results [12–14].
It may surprise the effectiveness of treatment with an anti CD-20 monoclonal antibody in a T-cell-mediated disease; however, changes in B and T lymphocytes after rituximab treatment in multiple sclerosis have been analyzed. Unexpectedly, after B-cell depletion, a decline in cerebrospinal fluid and blood T cells also occurred .
In this case, we started treatment with high-dose steroids, but it was insufficient to control the disease. Patient had an inadequate response to conventional immunosuppressive treatment, such as methotrexate, cyclosporine, and TNF blockers with constant recurrences. Consequently, we initiated rituximab therapy with an optimal control of inflammation. We achieved preservation of BCVA in RE, without relapsing inflammatory episodes, since we have started rituximab treatment.
To our knowledge, this is the first report of VKH disease treated with rituximab. Although experience in treatment of inflammatory eye disease with rituximab is reduced, this therapy might be considered a therapeutic alternative for treatment of patients with autoimmune ocular diseases, particularly those who have not previously responded to TNF blockers. Additional studies are warranted to confirm the efficacy of this new approach for inflammatory control in refractory cases of VKH disease.
Conflict of interest
No conflicting relationship exists for any author.
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.
- Vasconcelos-Santos DV, Sohn EH, Sadda S, Rao NA (2010) Retinal pigment epithelial changes in chronic Vogt–Koyanagi–Harada disease. Retina 30:33–41PubMedPubMed CentralView ArticleGoogle Scholar
- Díaz-Llopis M, Navea A, Peris C, Amselem L, Pinós J, Salom D, Hernández ML (2004) Síndrome de Vogt-Koyanagi-Harada, actualización. Studium Ophthalologicum 22:157–166Google Scholar
- Inomata H, Rao NA (2001) Depigmented atrophic lesions in sunset glow fundi of Vogt–Koyanagi–Harada disease. Am J Ophthalmol 131:607–614PubMedView ArticleGoogle Scholar
- Paredes I, Ahmed M, Foster CS (2006) Immunomodulatory therapy for Vogt–Koyanagi–Harada patients as first-line therapy. Ocul Immunol Inflamm 14:87–90PubMedView ArticleGoogle Scholar
- Tappeiner C, Heinz C, Specker C, Heilighenhaus A (2007) Rituximab as a treatment option for refractory endogenous anterior uveitis. Ophthalmic Res 39:184–186PubMedView ArticleGoogle Scholar
- Freidlin J, Wong IG, Acharya N (2007) Rituximab treatment for peripheral ulcerative keratitis associated with Wegener's granulomatosis. Br J Ophthalmol 91:1414PubMedPubMed CentralView ArticleGoogle Scholar
- Khanna D, Chong KK, Afifiyan NF, Hwang CJ, Lee DK, Garneau HC, Goldberg RA, Darwin CH, Smith TJ, Douglas RS (2010) Rituximab treatment of patients with severe, corticosteroid-resistant thyroid-associated ophthalmopathy. Ophthalmology 117:133–139PubMedPubMed CentralView ArticleGoogle Scholar
- Miserocchi E, Pontikaki I, Modorati G, Bandello F, Meroni PL, Gerloni V (2011) Rituximab for uveitis. Ophthalmology 118:223–224PubMedView ArticleGoogle Scholar
- Read RW, Yu F, Accorinti M, Bodaghi B, Chee SP, Fardeau C, Goto H, Holland GN, Kawashima H, Kojima E, Lehoang P, Lemaitre C, Okada AA, Pivetti-Pezzi P, Secchi A, See RF, Tabbara KF, Usui M, Rao NA (2006) Evaluation of the effect on outcomes of the route of administration of corticosteroids in acute Vogt–Koyanagi–Harada disease. Am J Ophthalmol 142:119–124PubMedView ArticleGoogle Scholar
- Niccoli L, Nannini C, Cassarà E, Gini G, Lenzetti I, Cantini F (2009) Efficacy of infliximab therapy in two patients with refractory Vogt–Koyanagi–Harada disease. Br J Ophthalmol 93:1553–1554PubMedView ArticleGoogle Scholar
- Díaz Llopis M, Amselem L, Romero FJ, García-Delpech S, Hernández ML (2007) Adalimumab therapy for Vogt–Koyanagi–Harada syndrome. Arch Soc Esp Oftalmol 82:131–132PubMedGoogle Scholar
- Khalifa Y, Loh AR, Acharya NR (2009) Fluocinolone acetonide intravitreal implants in Vogt–Koyanagi–Harada disease. Ocul Immunol Inflamm 17:431–433PubMedView ArticleGoogle Scholar
- Andrade RE, Muccioli C, Farah ME, Nussenblatt RB, Belfort R Jr (2004) Intravitreal triamcinolone in the treatment of serous retinal detachment in Vogt–Koyanagi–Harada syndrome. Am J Ophthalmol 137:572–574PubMedView ArticleGoogle Scholar
- Park HS, Nam KY, Kim JY (2011) Intravitreal bevacizumab injection for persistent serous retinal detachment associated with Vogt–Koyanagi–Harada disease. Graefes Arch Clin Exp Ophthalmol 249:133–136PubMedView ArticleGoogle Scholar
- Piccio L, Naismith RT, Trinkaus K, Klein RS, Parks BJ, Lyons JA, Cross AH (2010) Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis. Arch Neurol 67:707–714PubMedPubMed CentralView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.