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Table 2 Diagnostic criteria for initial-onset acute Vogt-Koyanagi-Harada diseasea

From: Vogt-Koyanagi-Harada disease: the step-by-step approach to a better understanding of clinicopathology, immunopathology, diagnosis, and management: a brief review

1. No ocular trauma or surgery preceding onset of diseaseb
2. Bilateral involvement (verified with ICGA and/or EDI-OCT)b
3. Exclusion of other infectious, inflammatory or masquerading entities, in particular other stromal choroiditis entities (i.e., tuberculosis, sarcoidosis or syphilis)b
4. Diffuse choroiditis evidenced by ICGA and/or EDI-OCTb
5. Signs and symptoms of less than 4 weeks’ durationb
6. Absence of clinical findings compatible with chronic disease (i.e. sunset glow fundus or integumentary signs (vitiligo, alopecia & poliosis)b
7. Exudative retinal detachments (evidenced by pooling and pinpoint leaking points on FA and ICGA) (very helpful criterion when present)
8. Disc hyperfluorescence (helpful criterion).
9. Neurological / auditory findings (meningismus, tinnitus, acute hearing loss) (helpful criterion).
  1. aReprinted from: Herbort CP Jr., et al. [39]
  2. bEssential criteria