Table 2 In vitro antibiotic susceptibility profiles of Nocardia keratitis isolates
From: Nocardia keratitis: amikacin nonsusceptibility, risk factors, and treatment outcomes
Nocardia Species | number of isolates | Amikacin | Tobramycin | Ciprofloxacin | Moxifloxacin | Clarithromycin | Doxycycline | Minocycline | Trimethoprim-Sulfa | Linezolid | Imipenem | Amoxicillin-Clavulanic Acid | Ceftriaxone | Cefepime |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nocardia amikacinitolerans | 11 | 0% | 82% | 0% | 9% | 0% | 36% | 100% | 100% | 100% | 18% | 100% | 27% | 0% |
Nocardia beijingensis | 3 | 33% | 100% | 0% | 0% | 0% | 33% | 100% | 100% | 100% | 0% | 100% | 67% | 67% |
Nocardia arthritidis | 2 | 100% | 50% | 33% | 50% | 50% | 50% | 50% | 100% | 100% | 0% | 50% | 50% | 50% |
Nocardia harenae | 1 | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% |
Nocardia farcinica | 1 | 100% | 0% | 0% | 100% | 0% | 0% | 0% | 100% | 100% | 100% | 100% | 0% | 0% |
Nocardia veterana | 1 | 100% | 0% | 0% | 0% | 100% | 0% | 0% | 100% | 100% | 100% | 0% | 0% | 100% |
N. asteroides complex | 1 | 0% | 100% | 0% | 0% | 0% | 0% | 0% | 100% | 100% | 0% | 0% | 0% | 0% |
N. endophytica | 1 | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 0% | 0% | 100% | 100% |
Nocardia bhagyanarayanae | 1 | 100% | 100% | 0% | 0% | 0% | 0% | 100% | 100% | 100% | 0% | 100% | 0% | 100% |
Nocardia testacea | 1 | 0% | 100% | 0% | 0% | 100% | 100% | 100% | 100% | 100% | 0% | 100% | 100% | 0% |
N. beijingensis/pneumoniae | 1 | 100% | 100% | 100% | 100% | 0% | 0% | 100% | 100% | 100% | 100% | 0% | 100% | 100% |
Nocardia beijingensis/pneumoiae/avagensis | 1 | 0% | 100% | 0% | 0% | 0% | 0% | 0% | 100% | 100% | 100% | 100% | 100% | 0% |
% Susceptible | 36% | 80% | 16% | 24% | 20% | 36% | 80% | 100% | 100% | 28% | 80% | 44% | 32% | |
% Resistant | 64% | 12% | 80% | 60% | 80% | 8% | 0% | 0% | 0% | 44% | 12% | 24% | 60% | |
% Intermediate | 0% | 8% | 4% | 16% | 0% | 56% | 20% | 0% | 0% | 28% | 8% | 32% | 8% | |
MIC50 (ug/ml) | < 32 (R) | < 1 (S) | > 4 (R) | > 4 (R) | > 16 (R) | < 2 (I) | < 1 (S) | < 0.5 (S) | < 2 (S) | > 8 (R) | < 4 (S) | 16 (I) | > 32 (R) | |
MIC90 (ug/ml) | > 64 (R) | > 12.8(R) | > 4 (R) | > 8 (R) | > 16 (R) | > 6.4(R) | 3.2 (I) | 3.9 (S) | 3.2 (S) | > 51.2(R) | > 25.6(R) | > 64 (R | > 32 (R) |