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Table 3 Diagnostic criteria for neurosarcoidosis [34]

From: An atypical case of neurosarcoidosis presenting with neovascular glaucoma

Proposed criteria for the diagnosis of neurosarcoidosis

Definite

• Positive nervous system histology

• Clinical presentation suggestive of neurosarcoidosis

Probable

• Clinical syndrome suggestive of neurosarcoidosis

• Laboratory support for central nervous system inflammation*

• Evidence for systemic sarcoidosis**

• Exclusion of alternative diagnosis

Possible

• Clinical presentation suggestive of neurosarcoidosis

• Exclusion of alternative diagnoses where the above criteria are not met

  1. *Elevated levels of cerebrospinal fluid protein and/or cells—the presence of oligoclonal bands and/or MRI evidence compatible with neurosarcoidosis
  2. **Positive histology—Kveim test—at least two indirect indicators from gallium scan, chest imaging, and serum ACE