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Table 3 Interleukin (IL) genes that have been suggested to be associated with VKH disease

From: Influence of molecular genetics in Vogt-Koyanagi-Harada disease

IL genes Polymorphisms associated with VKH disease Functional relevance Race References
IL-12B rs3212227 C allele of rs3212227 of IL-12B is a risk factor of VKH disease. IL-12B is suggested to enhance Th1 production which is involved in the pathogenesis of VKH disease. Chinese Han Li et al. [[67]]
IL-17F rs763780 TT genotype of IL-17F-rs763780 predisposes susceptibility to VKH disease, whereas the C allele of rs763780 may have protective effects against VKH disease. Chinese Han Shu et al. [[69]]
IL-23R None discovered yet. IL-23 levels are increased in the serum of VKH patients with active uveitis. IL-23 enhances production of IL-27 by CD4+ T cells. Chinese Han Jiang et al. [[73]]
IL-27 None discovered yet. IL-27 is suggested to promote Th17 production which is involved in the pathogenesis of VKH disease. Chinese Han Yang et al. [[57]]