Table 3 Interleukin (IL) genes that have been suggested to be associated with VKH disease
From: Influence of molecular genetics in Vogt-Koyanagi-Harada disease
IL genes | Polymorphisms associated with VKH disease | Functional relevance | Race | References |
|---|---|---|---|---|
IL-12B | rs3212227 | C allele of rs3212227 of IL-12B is a risk factor of VKH disease. IL-12B is suggested to enhance Th1 production which is involved in the pathogenesis of VKH disease. | Chinese Han | Li et al. [[67]] |
IL-17F | rs763780 | TT genotype of IL-17F-rs763780 predisposes susceptibility to VKH disease, whereas the C allele of rs763780 may have protective effects against VKH disease. | Chinese Han | Shu et al. [[69]] |
IL-23R | None discovered yet. | IL-23 levels are increased in the serum of VKH patients with active uveitis. IL-23 enhances production of IL-27 by CD4+ T cells. | Chinese Han | Jiang et al. [[73]] |
IL-27 | None discovered yet. | IL-27 is suggested to promote Th17 production which is involved in the pathogenesis of VKH disease. | Chinese Han | Yang et al. [[57]] |