Table 1 Major HLA genotypes associated with VKH disease
From: Influence of molecular genetics in Vogt-Koyanagi-Harada disease
HLA genotype association | Major findings | Race | References |
|---|---|---|---|
HLA-DQA1*0301 | 100% of 57 VKH patients vs. 67.2% of 122 control subjects | Japanese | Islam et al. [[24]] |
HLA-DQB1*0604 | 0% of 57 VKH patients vs. 15.6% of 122 control subjects, i.e., may be protective against VKH disease | Japanese | Islam et al. [[24]] |
HLA-DRB1*0404 | 25% of 76 VKH patients vs. 9.8% of 256 healthy individuals | Mexican Mestizo | Alaez et al. [[40]] |
HLA-DRB1*0405 | 95% of 40 VKH patients vs. 58.2% of DR4-positive healthy controls | Japanese | Shindo et al. [[28]] |
54.1% of 37 VKH patients have HLA-DRB1*0405 with a relative risk of 11.76 over the general population | Highly admixed Brazilian | Goldberg et al. [[34]] | |
82.3% of 18 VKH patients vs. 9.3% of 128 control subjects | Korean | Kim et al. [[35]] | |
36.6% of 30 VKH patients vs. 6.9% of 29 control subjects | Saudi Arabian | Iqniebi et al. [[36]] | |
13.2% of 76 VKH patients vs. 0.4% of 256 healthy individuals | Mexican Mestizo | Alaez et al. [[40]] |