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Table 1 Major HLA genotypes associated with VKH disease

From: Influence of molecular genetics in Vogt-Koyanagi-Harada disease

HLA genotype association Major findings Race References
HLA-DQA1*0301 100% of 57 VKH patients vs. 67.2% of 122 control subjects Japanese Islam et al. [[24]]
HLA-DQB1*0604 0% of 57 VKH patients vs. 15.6% of 122 control subjects, i.e., may be protective against VKH disease Japanese Islam et al. [[24]]
HLA-DRB1*0404 25% of 76 VKH patients vs. 9.8% of 256 healthy individuals Mexican Mestizo Alaez et al. [[40]]
HLA-DRB1*0405 95% of 40 VKH patients vs. 58.2% of DR4-positive healthy controls Japanese Shindo et al. [[28]]
54.1% of 37 VKH patients have HLA-DRB1*0405 with a relative risk of 11.76 over the general population Highly admixed Brazilian Goldberg et al. [[34]]
82.3% of 18 VKH patients vs. 9.3% of 128 control subjects Korean Kim et al. [[35]]
36.6% of 30 VKH patients vs. 6.9% of 29 control subjects Saudi Arabian Iqniebi et al. [[36]]
13.2% of 76 VKH patients vs. 0.4% of 256 healthy individuals Mexican Mestizo Alaez et al. [[40]]