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Table 3 Grading criteria for clinical symptom and signs

From: Phase II placebo-controlled study of nepafenac ophthalmic suspension 0.1% for postoperative inflammation and ocular pain associated with cataract surgery in Japanese patients

 

Grading criteria

Ocular pain

0: None—absence of pain

1: Trace—slight sensation of pain or discomfort

2: Mild—mild, tolerable aching of the eye

3: Moderate—moderate and prolonged aching sufficient to require the use of analgesics

4: Moderately severe—prolonged intense aching requiring the use of analgesics

5: Severe—prolonged sharp ocular or periocular pain

Flare

Use a 1 mm wide beam of the slit lamp aimed at the center of the pupil

0: None—no visible flare when compared with the normal eye

1: Mild—flare visible against dark pupillary background but not visible against iris background

2: Moderate—flare is visible with the slit lamp beam aimed onto the iris surface as well as the dark pupillary background

3: Severe very dense flare. May also present as a “hazy” appearance of anterior segment structures when viewed with low power magnification of the slit lamp. Presents as a pronounced Tyndall effect

Cell

Use narrow slit beam (0.5 mm in width and at least 8 mm in length) at maximum luminance. Pigment and red blood cells are to be ignored.

0: None

1: 1 to 5 cells

2: 6 to 15 cells

3: 16 to 30 cells

4: Greater than 30 cells