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Open Access

Subretinal pigment epithelial infiltrates in primary vitreoretinal lymphoma

  • Daniel Vítor Vasconcelos-Santos1, 2, 3Email author,
  • Gustavo Henrique De Puy e Souza1,
  • Bernardo Bacelar de Faria1,
  • Moisés Salgado Pedrosa1,
  • André Vasconcellos Diniz2,
  • Juliana Lambert Oréfice2,
  • Rogério Alves Costa2 and
  • Fernando Oréfice2
Journal of Ophthalmic Inflammation and Infection20111:34

Received: 10 June 2011

Accepted: 18 July 2011

Published: 6 August 2011


Public HealthLymphomaOptical Coherence TomographyLymphoma CellPigment Epithelium
A 67-year-old woman with chronic bilateral intraocular inflammation associated with vitreous cells and subretinal pigment epithelium (RPE) infiltrates (A–B) underwent a chorioretinal biopsy in the left eye after three negative vitreous biopsies. Sub-RPE deposits on spectral domain optical coherence tomography (C) corresponded to collections of diffuse large B-cell lymphoma cells on histopathogy (D–E) and immunohistochemistry (F–H).



The authors acknowledge Victório Vinciguerra Neto, COMT for his work in capturing part of the images.

Conflict of interest

The authors have no financial interest to disclose.

Authors’ Affiliations

Department of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Centro Brasileiro de Ciências Visuais, Belo Horizonte, Brazil
, Belo Horizonte, Brazil


© The Author(s) 2011

This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.