Presumed Sympathetic Ophthalmia after Scleral Buckling Surgery: Case Report


 Background: We aimed to report a rare case of presumed sympathetic ophthalmia (SO) in a young female patient following scleral buckling (SB). As SB is usually considered an extraocular operation, it is presumed to have low risk of SO.Case Presentation: A nineteen year-old female patient was referred for visual loss in her left eye because of macula off inferior longstanding rhegmatogenous retinal detachment (RD). Best corrected visual acuity (BCVA) was 20/400 in the left eye. SB with 360 degrees encircling band and inferior segmental tire, with one spot cryoretinopexy at the break site and subretinal fluid drainage was performed. One week after operation, visual acuity was improved to 20/80 and retina was totally attached. Six weeks later, patient came with severe visual loss in both eyes as counting finger 1 meter. Bilateral multifocal serous RD and vitreous cells was found. The patient was treated with intravenous corticosteroid pulse therapy and mycpphenolate mofetile as a case of sympathetic ophthalmia. The inflammation was controlled and serous RD resolved after five days intravenous treatment and was not relapsed after six months. BCVA was 20/20 in right eye and 20/50 in the left eye. Systemic workup was negative for any extraocular disease or systemic involvement.Conclusion: As SB usually considered as a procedure without manipulating intraocular tissues, it is considered to have low risk for SO. In this report, we have shown that SO may occur after successful SB. Inciting the choroid and retinal pigment epithelium with cryoretinopexy or perforating for drainage may induce SO.


Introduction
Sympathetic ophthalmia (SO) is a rare bilateral diffuse granulomatous panuveitis that may occur after surgery or trauma to one eye, as penetrating injury and exposure of the uvea. 1 The incidence of SO is reported ranging 0.01-0.5% after intraocular surgery. [1][2][3][4][5] Surgeries with manipulation and irritation of the choroid and retina are considered as risk factors. 1 The interval between the ocular injury and the onset of SO varies greatly, from a few days to decades, with most of the cases occurring within 3 months after the injury to the exciting eye and 90% during the rst year. [2][3][4] The inciting ocular surgery varies, including cataract extraction, secondary intraocular lens placement, trabeculectomy, vitrectomy, cyclodestruction, iridectomy, and evisceration. 1 Recently, there has been an increasing trend of SO incidence after intraocular and vitreoretinal surgeries. 6 Scleral buckling (SB) is usually considered an extraocular operation, a privilege over vitrectomy, and SO is presumed to have a very low risk after SB. Here we report an unusual rare case of SO following successful SB surgery which was combined with subretinal uid drainage (SRFD) and cryoretinopexy.

Case Presentation
A nineteen-year-old female was referred for visual loss and superior visual eld defect in her left eye (LE). Best corrected visual acuity (BCVA) was 20/20 and 20/400 in the right eye (RE) in the LE, respectively.
The anterior segment examination was within normal limits except for the detection of Shaffer sign in the LE. The results of the fundus examination revealed macula off inferior long-standing rhegmatogenous retinal detachment (RRD), three hours of proliferative vitreoretinopathy (PVR), retinal break, and lattice degeneration. The patient had no history of head or ocular trauma or any intraocular surgery. SB with 360 degrees encircling silicone band (silicone band type 240, FCI Inc., Paris, France) and inferior segmental silicone tire (asymmetrical silicone tire type 276, FCI Inc., Paris, France) with one spot cryoretinopexy at the break site, and SRFD due to chronicity of the RRD was performed. During this process, SRFD was not inadvertent. Scleral thinning was performed after passing the band and tire. Moreover, the needle of polyester spatula suture (Mersilene, Ethicon LLC, Johnson and Johnson Inc., USA) was used to drain the uid after the cauterization of the choroid. BCVA was improved to 20/80 and the retina was totally attached one week after the operation. The patient was followed up receiving a topical antibiotic junction was not detected due to diffuse severe choroidal thickening. According to the results of examination and imaging, as well as the absence of any other ocular trauma history except for SB surgery, the diagnosis of SO was presumed incited by SB surgery. Therefore, the patient was admitted and received high-dose (1 g/day) intravenous methylprednisolone treatment for 5 days. This ve-day pulse therapy led to the control of in ammation and the signi cant resolution of SRD ( Figure 2). The patient underwent all systemic work-ups for common causes of choroiditis, including sarcoidosis, tuberculosis, syphilis, and autoimmunity markers were inconclusive. Moreover, familial, drug, and past medical history were unremarkable. After pulse therapy, oral prednisolone (50 mg/day) and mycophenolate mofetil (MMF) (2 gr/day) were initiated. On the fourth day, uorescein angiography showed no signi cant dye pooling except for mild leakage; also, it revealed mixed hypo-and hyperuorescent dots scattered at the posterior poles presumably due to choroidal hypoperfusion and abnormal leakage. Since indocyanine green angiography (ICGA) was not available at that time, it was not performed at the rst presentation of SO. Prednisolone tapered rapidly due to the increased blood glucose, and subtenon triamcinolone acetonide (TriamHEXAL, Hexal AG, Holzkirchen, Germany) (40 mg/1 cc) was injected bilaterally. Induced diabetes was controlled with oral medication which was stopped after 1 month. Prednisolone was reached to 5 mg/d at the end of the second month with continuing MMF (2 gr/d). The blood glucose was checked frequently, which was within normal limits during the follow-up and did not relapse during 6-months follow-ups. Following one-year treatment with MMF 2 g/d and prednisolone 5 mg/d, in ammation was reduced considerably and the retina was attached completely in both eyes. Final BCVA was obtained as 20/20 and 20/50 in the RE and LE, respectively. After 3 months of immunosuppressive treatment, ICGA disclosed only a few hypo uorescent dark dots in both eyes and mild background hyper orescence at the posterior pole indicating a response to treatment with mild subclinical in ammation of choroidal stroma (Figure 2).

Discussion
Here, we report a rare case of SO following uncomplicated SB surgery accompanied by cryoretinopexy and SRFD. In this regard, it is recommended that SO be taken into consideration in any case of bilateral panuveitis associated with multiple SRD and a history of penetrating ocular surgery.
In several studies, the occurrence of SO has been reported after vitreoretinal surgery. 2, 4-6 It is postulated that trauma to the uveal tract in the context of inadvertent perforation, SRFD, or cryotherapy during SB surgery might be related to deliberate uveal antigens, melanin or outer photoreceptor antigens resulting to access to the lymphatic systems of the conjunctival tissue. This process may associated to exciting of delayed hypersensitivity reaction inside the eye. [4][5][6] The mechanism of hypersensitivity in the sympathizing eye may be due to the exposure of the uveal tissue to the conjunctival lymphatic system leading to a cell-mediated immune response. 6 This mechanism, owing to more uveal incarceration, can explain the relationship between an increase in the trend of transconjunctival sutureless vitrectomy application and a growth in the incidence of SO following vitreoretinal surgery. 6 In our case, SRFD seemingly increased the risk of uveal exposure to conjunctival lymphatic tissue. In a study conducted by Kilmartin et al., it was reported that RRD surgery was the most common procedure associated with the development of SO, with the risk of SO after vitrectomy being as twice as that of external scleral buckling, without any gender predilection. 7 The onset of SO symptoms after the operation usually occurs between 3 weeks and 6 months after surgery due to delayed hypersensitivity. 8 Regarding the subject in this study, SO was developed 6 weeks later. In a case series study carried out by Ozbek et al. 9 , three cases of SO incidence occurred following SB; however, two patients had combined vitrectomy with SB. In the aforementioned research, SO occurred only in one case after encircling buckle combined with 360 indirect retinal photocoagulations and SRFD, in contrast to our case that had only one cryoretinopexy spot and one drainage site. In another similar case report by Parvaresh and Falavarjani, SO was found in a case with a history of SB revision after 4 years. In this case, the second surgery was combined with SRFD and cryoretinopexy. 10 Nonetheless, in our case, SO happened in the rst operation without any surgical history.
In a recent study performed by Tyagi et al., the incidence of SO following vitreoretinal surgery was estimated at 0.038% of all vitrectomy cases, and vice versa, 9% of all cases of SO had vitreoretinal surgery. 6 In this research, 75% of cases underwent multiple ocular surgeries before the development of SO. 6 Furthermore, the most common anterior segment was non-granulomatous uveitis in 50% of subjects, in contrast to SRD occurring in 62.5% of cases. 6 In our case, it was found that anterior segment in ammation was less severe than the posterior segment chorioretinal ndings.
Most of the cases presented in studies 5-10 had simultaneous SB and vitrectomy, previous trauma, or multiple surgeries. Nevertheless, the subject of our report had no extensive retinal or uveal tissue manipulation and no combined surgery or previous surgery, highlighting the importance of this report.
One of the underlying reasons for this susceptibility might be related to the Asian ethnicity and higher prevalence of Vogt-Koyanagi-Harada (VKH) in this region.
One of the most important differential diagnoses of our case is related to VKH which is a common uveitis etiology with similar clinical and imaging ndings with SO. 1,11 Although sympathizing eye in SO presents clinically with nongranulomatous uveitis at rst, it progresses to granulomatous uveitis afterward. 8 shows three successive stages: posterior uveitis, anterior segment involvement associated with posterior uveitis, and nally anterior granulomatous uveitis. Both anterior and posterior uveitis are present in SO patients within 2 weeks of disease onset. 8  days after the steroid therapy, hyper uorscence was less prominent than hypo uorescence that was compatible with the location of granuloma and cellular in ltration. The most common features of ICGA imaging are multiple hypocyanescent spots. In the acute phase of SO, EDI-OCT discloses multiple SRD associated with hyperre ective septa, massive choroidal thickening, and loss of normal choroidal vascular architectures, as well as irregular photoreceptor outer segments similar to what was observed in the acute phase of VKH. The visual outcome is worse in SO as compared with VKH disease. 8 Moreover, BCVA was improved in our case due to early diagnosis and prompt, aggressive, and adequate treatment.
In conclusion, the diagnosis of sympathetic ophthalmia should be taken into account in any case of bilateral uveitis or bilateral SRD following scleral buckling with uveal tract violation, such as cryopexy or SRFD.