Table 2 Principal findings of articles regarding infectious uveitis and DED
From: Clinical relationship between dry eye disease and uveitis: a scoping review
Author | Title | Design of study | N total N uveitis N uveitis and DED | Gender | Localization of uveitis | Etiology | Mean age of uveitis presentation (years) | DED test | Relationship between diseases |
|---|---|---|---|---|---|---|---|---|---|
Merle H et al. [41], 2002 | Ocular lesions in 200 patients infected by the human T-cell lymphotropic virus type 1 in Martinique (French West Indies) | Case series | 200 29 11 | Male: 11 Female:18 | - Panuveitis 10/29. - Intermediate and posterior 4/29. - Intermediate 5/29. - Anterior and intermediate 7/29 - Anterior 3/29. | Human lymphocytic virus - Type 1200/200 | 55.6 | 11/29 patients had KCS. A diagnosis of KCS was made when 2 out of 3 of the following tests were positive: Schirmer test 1 < 10 mm, BUT < 10 seconds, rose bengal staining score > 3 points (Van-Bijsterveld score) | Uveitis group had a slightly higher prevalence of KCS 37.9% (11/29) vs non-Uveitis group 36.8% (63/171) |
Öztürk C et al. [42], 2021 | Bilateral Acute Anterior Uveitis and Corneal Punctate Epitheliopathy in Children Diagnosed with Multisystem Inflammatory Syndrome Secondary to COVID-19 | Case series | 5 5 3 | Male: 1 Female: 4 | Anterior 5/5 | SARS COV 2 5/5 | 9.4 | 3/5 patients with uveitis had an abnormal Schirmer test (≤ 7 mm) and corneal fluorescein staining (≥ 2 on the modified Oxford scale) | Description of 5 pediatric patients with uveitis secondary to COVID 19 infection, 60% (3/5) with abnormalities in ocular surface and tear function test |
Hoeksema L et al. [43], 2017 | Risk Factors for Secondary Glaucoma in Herpetic Anterior Uveitis | Cross-sectional study | 73 73 25 | Male: 45 Female: 28 | Anterior 73/73 | - Herpes simplex virus 54/73 - Varicela zoster virus 19/73 | 50 | N/A | Dry eye was the third most common complication 34% (25/73) after Keratitis 59% (43/73) and Elevated IOP 75% (55/73) in uveitis secondary to herpes infection |
Babu K et al. [44], 2020 | Diagnostic Markers in Ocular Sarcoidosis in A High TB Endemic Population–A Multicentre Study | Case–control study | 368 368 43 | Male: 193 Female: 175 | - Panuveitis 112/368 - Posterior 138/368 - Intermediate 53/368 - Anterior 58/368 - Others 7/368 | - Sarcoidosis 61/368 (Group A - GA) - Tuberculosis 307/368 (Group B - GB) | GA: 43 GB: 38 | 36/42 patients from sarcoidosis group had a low Schirmer test (≤ 10 mm) 7/42 patients from the tuberculosis group had a low Schirmer test (≤ 10 mm) | Schirmer tests were significantly lower in patients with Sarcoidosis 85.7% (36/42) than in Ocular tuberculosis 16.6% (7/42) which could help differentiate ocular sarcoidosis in a high TB endemic population (OR:30, CI 95%) |