Fig. 2

Imaging and histopathologic findings in a patient with an inflammatory reaction after RPE-choroid transplantation. Imaging (A-E) and histopathologic examination (F-I) of patient 2. Fundus shows a leopard-like pattern on the graft (A). At the time of inflammation fluorangiography shows no recurrence (B) and indocyanine green angiography shows perfusion of the graft (C). OCT-image during inflammation shows subretinal fluid and hyperreflective spots (arrow heads) (D). No inflammatory reaction occurred in the second RPE-choroid transplant 21 months after re-transplantation (E). Histopathology of the explanted graft demonstrates presence of CD3 positive T-lymphocytes (F), showing both CD4 positive T-helper phenotype (G), and CD8 positive cytotoxic T cell phenotype (H), and CD68 positive macrophages (I) in the choroid and RPE. An increased number of CD20 positive B-cells (J), of which a few were CD138 positive plasma cells (K), was seen in the choroid but not in the RPE