Table 4 Top upstream regulators
Affected eyes of AAU patients versus eyes of healthy controls | Affected versus unaffected eyes of AAU patients | Affected eyes of bacterial keratitis patients versus eyes of healthy controls | Affected versus unaffected eyes of bacterial keratitis patients | ||||
|---|---|---|---|---|---|---|---|
Name | p-value | Name | p-value | Name | p-value | Name | p-value |
MAPT | 2.25E-26 | Lipopolysaccharide | 5.74E-31 | MAPT | 2.82E-25 | MAPT | 2.91E-22 |
APP | 2.90E-23 | Nitrofurantoin | 2.14E-30 | APP | 1.69E-22 | APP | 6.12E-20 |
TNF | 2.42E-18 | Dexamethasone | 6.35E-26 | PSEN1 | 1.32E-18 | TNF | 1.82E-17 |
TP53 | 1.54E-17 | Beta-estradiol | 1.21E-23 | TGFß1 | 2.21E-17 | TGFß1 | 3.99E-17 |
PSEN1 | 2.24E-17 | APP | 4.26E-21 | TNF | 4.41E-17 | IL6 | 1.73E-16 |