Factors associated with the development of ocular candidiasis and ocular prognosis with echinocandin therapy for candidemia

Journal of Ophthalmic Inflammation and Infection

Table 2 Results of logistic regression analysis of factors associated with the development of probable OC

Variable	Univariate analysis			Multivariate analysis
Variable	OR	95% CI	P value	aOR	95% CI	P value
Age per year	0.993	0.953–1.036	0.759
Sex (female/male)	9.000	1.598–50.691	0.013^†	8.927	1.093–72.944	0.041^†
Malignancy	2.333	0.499–10.907	0.282
Solid tumor	2.000	0.442–9.056	0.368
Hematological tumor	1.571	0.153–16.182	0.704
Diabetes mellitus	1.32	0.278–6.257	0.727
Corticosteroids use	2.018	0.415–9.815	0.348
Immunosuppressive drug use	3.364	0.721–15.701	0.123^a	2.885	0.316–26.350	0.348
Neutropenia	1.571	0.153–16.182	0.704
Recent systemic surgery (within 1 month)	0.914	0.194–4.301	0.909
IVH	1.000	0.178–5.632	1.000
Intravascular devices	0.467	0.042–5.140	0.534
Blood β-D-glucan > 20 pg/mL	0.655	0.138–3.472	0.457
Heart failure	0.481	0.053–4.34	0.514
Kidney failure	0.509	0.093–2.79	0.436
Elevated liver enzymes	0.412	0.09–1.881	0.252
Hypertension	1.000	0.213–4.693	1.000
Anemia	1.000	0.104–9.614	1.000
Thrombocytopenia	0.394	0.072–2.152	0.282
Collagen-related disease	1.000	0.104–9.614	1.000
Previous history of ophthalmic surgery	0.314	0.035–2.787	0.299
Candida species (Candida albicans/non-albicans)	14.000	1.583–123.79	0.018^†	23.624	1.984–281.289	0.012^†

OC Ocular candidiasis, OR Odds ratio, aOR adjusted OR, CI Confidence interval, IVH Intravenous hyperalimentation
^a Identified as potentially relevant
† Statistically significant at the P < 0.05 level