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Table 1 Clinical characteristics of the patients with and without probable OC

From: Factors associated with the development of ocular candidiasis and ocular prognosis with echinocandin therapy for candidemia

 

Overall

Patients with probable OC

Patients without probable OC

P value

(n = 56)

(n = 8)

(n = 48)

Age (years), mean (SD)

67.6 ± 17.1

65.9 (20.0)

69.3 (14.4)

0.759

Female, n (%)

18 (32.1)

6 (75.0)

12 (25.0)

0.013†

Malignancy, n (%)

25 (44.6)

5 (62.5)

20 (41.7)

0.282

Solid tumor

20 (35.7)

4 (50.0)

16 (33.3)

0.368

Hematological tumor

5 (8.9)

1 (12.5)

4 (8.3)

0.704

Diabetes mellitus, n (%)

18 (32.1)

3 (37.5)

15 (31.3)

0.727

Corticosteroids use, n (%)

14 (25.0)

3 (37.5)

11 (22.9)

0.384

Immunosuppressive drug use, n (%)

15 (26.8)

4 (50.0)

11 (22.9)

0.123b

Neutropenia, n (%)

5 (8.9)

1 (12.5)

4 (8.3)

0.704

Recent systemic surgery (within 1 month), n (%)

36 (64.3)

5 (62.5)

31 (64.6)

0.909

IVH

42 (75.0)

6 (75.0)

36 (75.0)

1.000

Intravascular devices

52 (92.9)

7 (87.5)

45 (93.8)

0.534

Blood β-D-glucan (pg/mL), mean (SD) (n = 36)

98.4 (161.5)

   

Blood β-D-glucan > 20 pg/mL, n (%) (n = 36)

16 (44.4)

3 (60.0)

13 (41.9)

0.655

Heart failure, n (%)

12 (21.4)

1 (12.5)

11 (22.9)

0.514

Kidney failure, n (%)

21 (37.5)

2 (25.0)

19 (39.6)

0.436

Elevated liver enzymes, n (%)

38 (67.9)

4 (50.0)

34 (70.8)

0.252

Hypertension, n (%)

21 (37.5)

3 (37.5)

18 (37.5)

1.000

Anemia, n (%)

49 (87.5)

7 (87.5)

42 (87.5)

1.000

Thrombocytopenia, n (%)

24 (42.9)

2 (25.0)

22 (45.8)

0.282

Collagen-related disease, n (%)

7 (12.5)

1 (12.5)

6 (12.5)

1.000

Previous history of ophthalmic surgery, n (%)

16 (28.6)

1 (12.5)

15 (31.3)

0.299

Candida species, n (%)

 Candida albicans

23 (41.1)

7 (87.5)

16 (33.3)

0.018a†

 Candida parapsilosis

14 (25.0)

1 (12.5)

13 (27.1)

0.392 a

 Candida glabrata

7 (12.5)

0 (0.0)

7 (14.6)

 

 Candida tropicalis

7 (12.5)

0 (0.0)

7 (14.6)

 

 Candida krusei

3 (5.4)

0 (0.0)

3 (6.3)

 

 Other Candida species

2 (3.6)

0 (0.0)

2 (4.2)

 
  1. OC Ocular candidiasis, SD Standard deviation, IVH Intravenous hyperalimentation
  2. a Compared with other Candida species
  3. b Identified as potentially relevant
  4. † Statistically significant at the P < 0.05 level