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Table 3 Characteristics of included studies. *Demographic data for this study was stratified by uveitis severity. ICD, International Classification of Diseases, ILAR, International League of Associations for Rheumatology; IUSG, International Uveitis Study Group; JIA, juvenile idiopathic arthritis, JIA-U, juvenile idiopathic arthritis associated uveitis; SD, standard deviation; SUN, Standardisation of Uveitis Nomenclature

From: “Environmental risk factors associated with juvenile idiopathic arthritis associated uveitis: a systematic review of the literature”

Study Study type Country Sample size Age of JIA onset, cases (mean ± SD, years) Age of JIA onset, controls (mean ± SD, years) Sex of cases (Female, %) Sex of controls (Female, %) Risk factors Diagnostic criteria JIA subtypes included JIA-U subtypes included
Zulian, 2002 [13] Cohort Italy 316 2.42 ± 1.5 (mild)*, 3.17 ± 1.75 (severe)* 3.08 ± 1.75 89.01 (mild)*, 74.36 (severe)* 78.26 Seasonality ILAR-1997, IUSG 1987 Oligoarticular JIA only No/mild/severe uveitis
Cole, 2013 [14] Cohort USA 297 7.2 10.2 76.19 65.10 “Allergy” or “Allergic” in medical records, allergy medication use ICD-9 All (ICD-9 codes 696.0, 714.0, 714.2, 714.3, 714.9, 720.2, 720.9) Acute and chronic iridocyclitis (ICD-9 codes 364.00 and 364.10)
Sengler, 2018 [15] Cohort Germany 360 4.0 ± 2.9 7.8 ± 4.6 73.7 66.2 Vitamin D ILAR 2001, SUN 2005 All Any