Table 3 Characteristics of included studies. *Demographic data for this study was stratified by uveitis severity. ICD, International Classification of Diseases, ILAR, International League of Associations for Rheumatology; IUSG, International Uveitis Study Group; JIA, juvenile idiopathic arthritis, JIA-U, juvenile idiopathic arthritis associated uveitis; SD, standard deviation; SUN, Standardisation of Uveitis Nomenclature
Study | Study type | Country | Sample size | Age of JIA onset, cases (mean ± SD, years) | Age of JIA onset, controls (mean ± SD, years) | Sex of cases (Female, %) | Sex of controls (Female, %) | Risk factors | Diagnostic criteria | JIA subtypes included | JIA-U subtypes included |
|---|---|---|---|---|---|---|---|---|---|---|---|
Zulian, 2002 [13] | Cohort | Italy | 316 | 2.42 ± 1.5 (mild)*, 3.17 ± 1.75 (severe)* | 3.08 ± 1.75 | 89.01 (mild)*, 74.36 (severe)* | 78.26 | Seasonality | ILAR-1997, IUSG 1987 | Oligoarticular JIA only | No/mild/severe uveitis |
Cole, 2013 [14] | Cohort | USA | 297 | 7.2 | 10.2 | 76.19 | 65.10 | “Allergy” or “Allergic” in medical records, allergy medication use | ICD-9 | All (ICD-9 codes 696.0, 714.0, 714.2, 714.3, 714.9, 720.2, 720.9) | Acute and chronic iridocyclitis (ICD-9 codes 364.00 and 364.10) |
Sengler, 2018 [15] | Cohort | Germany | 360 | 4.0 ± 2.9 | 7.8 ± 4.6 | 73.7 | 66.2 | Vitamin D | ILAR 2001, SUN 2005 | All | Any |