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Table 1 A brief review of some of the recent reports of CMV retinitis in immunocompetent patients. (Abbreviations: Diabetes mellitus (DM), injection of triamcinolone acetonide (IVTA), central retinal vein occlusion (CRVO))

From: Long-term prophylaxis in an immunocompetent patient with Cytomegalovirus retinitis: a case report and review of literature

case (Reference)AgeLateralitySystemic and ocular historyManifestationTreatmentInitial visual acuityFinal visual acuity
1 [1]61Right eyeNoneFine keratic precipitates, 1+ aqueous cells, mild vitritis, patches of hemorrhagic retinitis and perivascular sheathingIntravitreal ganciclovir followed by oral valganciclovir4/208/20
2 [9]51Both eyesNoneFine keratic precipitates, 1+ aqueous cell, and flare, 1+ vitritis in both eyes, areas of confluent retinitis and hemorrhage and peripheral necrosis and fibrosisOral valganciclovir20/60 (right eye) and 20/50
(left eye)
20/70 (right eye)
and 20/60 (left eye)
3 [5]75Left eyeDiabetes mellitus (DM), intravitreal injection of triamcinolone acetonide (IVTA)The rare cell in the anterior chamber, no vitreous cells, arcuate retinal whitening (which appeared full-thickness) along the temporal vascular arcadesIntravitreal ganciclovir followed by oral valganciclovir20/8020/400
4 [2]77Right eyeDM, IVTAFine keratic precipitates, 2 + vitritis, foci of oedematous retinitis with dense retinal whitening, hemorrhages and inflammatory retinal vascular sheathingIntravitreal injection of ganciclovir + intravenous administration
of ganciclovir followed by oral valganciclovir
counting fingers at 1.8 m20/200
5 [2]69Right eyeDM, central retinal vein occlusion (CRVO), Vitrectomy surgery, IVTAKeratic precipitates, 2 + cells in the anterior chamber, moderate vitritis, necrotizing retinitis extending throughout the entire retina with hemorrhages, retinal opacification and periphlebitisIntravitreal injection of ganciclovir + intravenous administration
of ganciclovir followed by oral valganciclovir
20/20020/400
6 [3]54Left eyeCarrier of human T-cell lymphotropic virus type 1, DM, CRVO, vitrectomy surgery, IVTASmall granulomatous keratic precipitates, 1+ aqueous cell and flare, 1+ vitritis, papillitis, retinal vasculitis, and retinal exudatesIntravenous injections of ganciclovir + Intravitreous
injections of foscarnet
1.00.5
7 [10]78Right eyeIVTAKeratic precipitates, 2+ cells in the anterior chamber and moderate vitritis, hemorrhagic sheathing of branch arteries, inflammatory vascular sheathings in the periphery and areas of retinal whitening in the peripheral superior nasal partIntravitreous injections of ganciclovir + intravenous ganciclovir followed by oral valganciclovir20/4020/25
8 [4]61Left eyeDM, intravitreal injection of bevacizumab4+ cells and in the anterior chamber, dense vitritis and retinal vascular obliteration, necrotizing retinitis with dense retinal whitening and hemorrhageIntravenous administration of ganciclovirHand motionsNot reported
9 [6]75Left eyeDM, intravitreal injection of ranibizumabMild anterior segment inflammation, low-grade vitritis, and foci of retinitis in the peripheral fundus along with retinal and subretinal hemorrhages, exudates, and macular edemaIntravitreal ganciclovir4/105/10
10 [11]74Right eyeMultiple intraocular surgeries, long-term use of immunosuppressive eye drops such as corticosteroids and cyclosporineNo inflammatory cells in the anterior chamber or the anterior vitreous, confluent exudate the entire peripheral retinaIntravenous ganciclovir+ intravitreal ganciclovir injections followed by oral valganciclovirHand motionsNot reported