Fig. 3
From: Interleukin-6 inhibition in the management of non-infectious uveitis and beyond
Pro- and anti-inflammatory activities of IL-6. Anti-inflammatory activities of IL-6 include STAT3-dependent regeneration of epithelial cells and the induction of the hepatic acute-phase response. These activities are dependent on the membrane-bound IL-6R. Pro-inflammatory activities of IL-6 include recruitment of inflammatory cells, inhibition of apoptosis of inflammatory cells, and inhibition of regulatory T cell differentiation. Adapted from “Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms.” by Luo Y, Zheng SG. Immunol. 2016; 7:604. [Copyright: Ivyspring International Publisher]