Fig. 1
From: Interleukin-6 inhibition in the management of non-infectious uveitis and beyond
IL-6 classic-signaling and IL-6 trans-signaling. IL-6 classic signaling requires membrane bound IL-6R and is restricted to hepatocytes, some epithelial cells and some leukocytes. IL-6 trans-signaling requires sIL-6R and is possible on all cells of the body since all cells express the gp130 protein. Adapted from “IL-6 trans-signaling via the soluble IL-6 receptor: Importance for the pro-inflammatory activities of IL-6.” by Rose-John S, Int J Biol Sci 2012; 8:1237-1247 [Copyright: Ivyspring International Publisher]