Table 3 Features of inflammatory choroidal neovascularization (CNV) commonly associated with non-infectious uveitis

Prevalence

33–50% cases

76–100% cases

10–25% cases

9–15%

Location of CNV

Associated with inflammatory lesions in the subfoveal or extrafoveal region

Highly focal; associated with inflammatory lesions in the macula

CNV is located near chorioretinal lesions in peripapillary, subfoveal, or extrafoveal areas

Usually extrafoveal; can be subfoveal and associated with chorioretinal scar

Morphology of CNV

CNV appear as subretinal elevations and subretinal fluid with or without associated hemorrhage, closely resembling inflammatory lesions

CNV appear as subretinal elevations and subretinal fluid with or without hemorrhage, closely resembling inflammatory lesions

CNV lesions are deep with associated chorioretinal atrophy, subretinal fibrosis, and pigment clumping

CNV lesions are deep, associated with subretinal or intraretinal fluid, with hemorrhage and exudation.

Associated inflammatory lesions

Multifocal choroiditis present with minimal vitreous inflammation with multiple punched-out, white-yellow lesions (50–200 μm) in the peripapillary, mid-peripheral, and anteriorly to the equator

The lesions are characterized by multiple, small (50–300 μm in diameter), yellow or white, opaque, round lesions scattered throughout the posterior pole, rarely extending to mid-periphery; absence of vitritis

Active lesions appear as gray-white lesions that progress in a geographic manner in the posterior fundus

VKH presents with granulomatous anterior uveitis, posterior synechiae, iris nodules, and stromal atrophy; multiple pockets of subretinal fluid with exudative detachments; sunset glow fundus in the chronic disease.