Endogenous endophthalmitis: diagnosis, management, and prognosis

Journal of Ophthalmic Inflammation and Infection

Table 3 Commonly used intravitreal antifungal drugs employed for pharmacotherapy of fungal endogenous endophthalmitis along with their sensitivity

Drug	Intravitreal dose	Systemic dose	Candida	Aspergillus	Others
A. Polyene
Amphotericin B	5 μg/0.1 ml	0.5–0.7 mg/kg (IV)	++	+
B. Imidazoles
Miconazole	25–50 μg/0.1 ml	–	+	+
Itraconazole	5 μg/0.05 ml	200–400 mg/day (oral)	+	+
Itraconazole	5 μg/0.05 ml	200 mg/day (IV)	+	+
Voriconazole	50–200 μg/0.1 ml	200 mg twice daily (oral)	+++	++	Fusarium +
Voriconazole	50–200 μg/0.1 ml	3–6 mg/kg (IV) twice daily	+++	++	Fusarium +
C. Pyrimidine
5-Flucytosine	2.25 mg/0.1 ml	25–37.5 mg/kg/day	−	+
D. Echinocandins
Caspofungin	–	50 mg/day	+	+