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Table 3 Commonly used intravitreal antifungal drugs employed for pharmacotherapy of fungal endogenous endophthalmitis along with their sensitivity

From: Endogenous endophthalmitis: diagnosis, management, and prognosis

Drug Intravitreal dose Systemic dose Candida Aspergillus Others
A. Polyene
Amphotericin B 5 μg/0.1 ml 0.5–0.7 mg/kg (IV) ++ +  
B. Imidazoles
Miconazole 25–50 μg/0.1 ml + +  
Itraconazole 5 μg/0.05 ml 200–400 mg/day (oral) + +  
200 mg/day (IV)
Voriconazole 50–200 μg/0.1 ml 200 mg twice daily (oral) +++ ++ Fusarium +
3–6 mg/kg (IV) twice daily
C. Pyrimidine
5-Flucytosine 2.25 mg/0.1 ml 25–37.5 mg/kg/day +  
D. Echinocandins
Caspofungin 50 mg/day + +  
  1. IV intravenous