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Table 3 Th e National eye institute 39-question visual function questionnaire scores analyzed by disease category

From: Assessment of changes in quality of life among patients in the SAVE Study - Sirolimus as therapeutic Approach to uVEitis: a randomized study to assess the safety and bioactivity of intravitreal and subconjunctival injections of sirolimus in patients with non-infectious uveitis

 

Category 1

Category 2

Category 3

Mean

P value

Mean

P value

Mean

P value

VFQ-25 subscales

BL

( n  = 7)

M6

( n  = 7)

M12

( n  = 4)

BL-M6

BL-M12

BL

( n  = 11)

M6

( n  = 11)

M12

( n  = 11)

BL-M6

BL-M12

BL

( n  = 8)

M6

( n  = 8)

M12

( n  = 8)

BL-M6

BL-M12

General health

73.98

73.47

73.21

0.93

0.39

76.62

75.32

74.03

0.73

0.44

56.25

65.18

67.41

0.26

0.11

General vision

50.48

58.57

70.00

0.38

0.08

66.06

76.36

73.33

0.03

0.27

67.50

72.50

70.42

0.14

0.65

Ocular pain

64.29

78.57

78.13

0.10

0.04

80.68

87.50

94.32

0.14

0.001

70.31

78.13

79.69

0.43

0.27

Near activities

54.52

57.98

63.33

0.66

0.12

73.48

76.89

79.17

0.23

0.16

78.65

75.00

75.00

0.49

0.30

Distance activities

64.76

69.35

71.88

0.52

0.06

77.27

84.09

82.58

0.01

0.29

77.08

82.81

84.27

0.36

0.18

Vision-specific social functioning

79.76

84.52

83.33

0.52

0.10

87.12

94.70

96.21

0.10

0.07

94.79

92.71

96.35

0.68

0.55

Vision-specific mental health

34.76

47.14

51.25

0.16

0.05

64.09

73.18

81.36

0.07

0.02

74.69

83.75

81.88

0.02

0.30

Vision-specific role difficulties

47.32

52.68

64.06

0.36

0.11

80.11

85.80

89.20

0.22

0.19

78.13

83.59

83.59

0.41

0.33

Vision-specific dependency

66.96

74.11

75.00

0.31

0.10

82.39

88.64

94.89

0.27

0.13

97.66

99.22

98.44

0.45

0.60

Driving

56.55

55.56

47.22

1.00

0.42

81.48

74.24

78.03

0.36

0.49

65.48

84.72

83.33

0.03

0.08

Color vision

85.71

92.86

93.75

0.46

0.18

88.64

95.45

93.18

0.39

0.44

96.88

96.88

96.88

NS

NS

Peripheral vision

75.00

82.14

75.00

0.57

0.64

84.09

87.50

84.09

0.57

1.00

75.00

76.56

75.00

0.83

1.00

Composite score for VFQ-39 (VFQ-25 + additional items)

61.83

68.70

71.09

0.21

0.03

78.18

84.03

86.03

0.03

0.08

79.78

84.04

84.13

0.15

0.09

  1. Italicized values indicate statistical significance.
  2. BL, baseline; M6, month 6; M12, month 12, VFQ, Visual Function Questionnaire, Category 1, active uveitis and receiving no treatment; Category 2, active uveitis and receiving ≥10 mg/day of prednisone and/or at least one other systemic immunosuppressant; Category 3, inactive uveitis and receiving <10 mg/day of prednisone and/or at least one other systemic immunosuppressant.