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Table 1 Pooled National Eye Institute 39-Question Visual Function Questionnaire composite and subscale scores

From: Assessment of changes in quality of life among patients in the SAVE Study - Sirolimus as therapeutic Approach to uVEitis: a randomized study to assess the safety and bioactivity of intravitreal and subconjunctival injections of sirolimus in patients with non-infectious uveitis

 

Median

P value

VFQ-25 subscales

BL ( n  = 26)

M6 ( n  = 26)

M12 ( n  = 23)

BL-M6

BL-M12

General health

69.6

71.7

71.6

0.51

0.28

General vision

62.3

70.4

71.7

0.01

0.07

Ocular pain

73.1

82.2

86.4

0.03

<0.001

Near activities

70.0

71.2

75.0

0.65

0.12

Distance activities

73.8

79.7

81.3

0.03

0.02

Vision-specific social functioning

87.5

91.3

94.0

0.21

0.02

Vision-specific mental health

59.5

69.4

76.3

<0.001

<0.001

Vision-specific role difficulties

70.7

76.2

82.9

0.07

0.02

Vision-specific dependency

82.9

88.0

92.7

0.09

0.03

Drivinga

69.0

72.1

75.0

0.31

0.10

Color vision

90.4

95.2

94.6

0.23

0.16

Peripheral vision

78.8

82.7

79.3

0.39

0.75

Composite score for VFQ-39

(VFQ-25 + additional items)

74.3

79.9

82.8

<0.001

<0.001

  1. Italicized values indicate statistical significance.
  2. aDriving: n = 21 for BL and M6, n = 18 for M12.
  3. BL, baseline; M6, month 6; M12, month 12, VFQ, Visual Function Questionnaire.