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Table 1 Pooled National Eye Institute 39-Question Visual Function Questionnaire composite and subscale scores

From: Assessment of changes in quality of life among patients in the SAVE Study - Sirolimus as therapeutic Approach to uVEitis: a randomized study to assess the safety and bioactivity of intravitreal and subconjunctival injections of sirolimus in patients with non-infectious uveitis

  Median P value
VFQ-25 subscales BL ( n= 26) M6 ( n= 26) M12 ( n= 23) BL-M6 BL-M12
General health 69.6 71.7 71.6 0.51 0.28
General vision 62.3 70.4 71.7 0.01 0.07
Ocular pain 73.1 82.2 86.4 0.03 <0.001
Near activities 70.0 71.2 75.0 0.65 0.12
Distance activities 73.8 79.7 81.3 0.03 0.02
Vision-specific social functioning 87.5 91.3 94.0 0.21 0.02
Vision-specific mental health 59.5 69.4 76.3 <0.001 <0.001
Vision-specific role difficulties 70.7 76.2 82.9 0.07 0.02
Vision-specific dependency 82.9 88.0 92.7 0.09 0.03
Drivinga 69.0 72.1 75.0 0.31 0.10
Color vision 90.4 95.2 94.6 0.23 0.16
Peripheral vision 78.8 82.7 79.3 0.39 0.75
Composite score for VFQ-39
(VFQ-25 + additional items)
74.3 79.9 82.8 <0.001 <0.001
  1. Italicized values indicate statistical significance.
  2. aDriving: n = 21 for BL and M6, n = 18 for M12.
  3. BL, baseline; M6, month 6; M12, month 12, VFQ, Visual Function Questionnaire.