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Table 5 Summary of genes which have been shown to be unrelated or with uncertain association with VKH disease

From: Influence of molecular genetics in Vogt-Koyanagi-Harada disease

Gene Subtype/polymorphism References
Complement factor H (CFH) 184G rs800292 showed increased risk with non-infectious intermediate and posterior uveitis but not in VKH. Yang et al. [[56]]
Tyrosinase gene family No significant association in polymorphisms of microsatellites loci in tyrosinase gene family was found in Japanese VKH patients. Horie et al. [[134]]
Interferon gamma No significant association in polymorphism of interferon gamma gene was found in Japanese VKH disease. Horie et al. [[137]]
NLR family, pyrin domain containing 1 (NLRP1) NLRP1 gene polymorphisms related to vitiligo were not associated with the risks or clinical manifestations of VKH disease. Horie et al. [[142]]
Toll-like receptor 9 (TLR9) gene No significant association between TLR9 polymorphisms and VKH disease was found in VKH patients. Ito et al. [[144]]
Transforming growth factor β receptor (TGF- β) Two SNPs of type III TGF-β receptor, rs1805110 and rs2489188, showed no association with VKH disease. Chen et al. [[148]]
Janus kinase 1 (JAK1) gene rs310230 GG genotype, rs310236 GG genotype, and rs310241 TT genotype were found in lower frequencies in VKH patients than controls. However, no significant link between the three SNPs and clinical manifestations of VKH disease was identified. Hu et al. [[150]]
Chemokine (C-C motif) receptor 6 (CCR6) No significant association in CCR6 SNPs including rs3093024, rs6902119, rs3093023, and rs968334 in Chinese VKH patients. Yi et al. [[160]]