Table 4 Summary of genes that have been shown to be related to increased risk of VKH disease
From: Influence of molecular genetics in Vogt-Koyanagi-Harada disease
Gene | Subtype/polymorphism | References |
|---|---|---|
Human leukocyte antigen (HLA) | HLA-DQ4 | Islam et al. [[24]] |
HLA-DQw7 | Zhang et al. [[25]] | |
DR1 | Weisz et el. [[30]] | |
DR4 | Islam et al. [[24]], Zhang et al. [[25]], Weisz et el. [[30]] | |
DR53 | Islam et al. [[24]] | |
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) | G allele at SNP +49, CTLA-4 haplotype −1661A:−318C:+49G:CT60G | Du et al. [[53]] |
Interleukin (IL) genes | IL-12B rs3212227 C allele | Li et al. [[67]] |
IL-17F rs763780 TT genotype | Shu et al. [[69]] | |
Killer cell immunoglobulin-like receptors (KIR) gene cluster | KIR2DS3, KIR gene cluster 3DS1-2DL5-2DS1-2DS5, KIR2DL2/2DL3+HLA-C1 | Sheereen et al. [[79]] |
Programmed cell death 1 (PDCD1) | PD-1.5 C allele | Meng et al. [[98]] |
Protein tyrosine phosphatase non-receptor 22 (PTPN22) | rs2488457 CC genotype and C allele | Zhang et al. [[107]] |
rs2488457 GG genotype | ||
Osteopontin (OPN) | rs4754 TT genotype | Chu et al. [[110]] |
Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) | rs9494885 TC genotype and C allele | Li et al. [[118]] |
Macrophage migration inhibitory factor (MIF) | rs755622 GG genotype and G allele, rs2096525 T allele, rs755622/rs2096525 CT haplotype | Zhang et al. [[128]] |
Fibroblast growth factor receptor 1 oncogene partner (FGFR1OP) | rs2301436 | Yi et al. [[160]] |