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Table 4 Summary of genes that have been shown to be related to increased risk of VKH disease

From: Influence of molecular genetics in Vogt-Koyanagi-Harada disease

Gene Subtype/polymorphism References
Human leukocyte antigen (HLA) HLA-DQ4 Islam et al. [[24]]
HLA-DQw7 Zhang et al. [[25]]
DR1 Weisz et el. [[30]]
DR4 Islam et al. [[24]], Zhang et al. [[25]], Weisz et el. [[30]]
DR53 Islam et al. [[24]]
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) G allele at SNP +49, CTLA-4 haplotype −1661A:−318C:+49G:CT60G Du et al. [[53]]
Interleukin (IL) genes IL-12B rs3212227 C allele Li et al. [[67]]
IL-17F rs763780 TT genotype Shu et al. [[69]]
Killer cell immunoglobulin-like receptors (KIR) gene cluster KIR2DS3, KIR gene cluster 3DS1-2DL5-2DS1-2DS5, KIR2DL2/2DL3+HLA-C1 Sheereen et al. [[79]]
Programmed cell death 1 (PDCD1) PD-1.5 C allele Meng et al. [[98]]
Protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2488457 CC genotype and C allele Zhang et al. [[107]]
rs2488457 GG genotype
Osteopontin (OPN) rs4754 TT genotype Chu et al. [[110]]
Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) rs9494885 TC genotype and C allele Li et al. [[118]]
Macrophage migration inhibitory factor (MIF) rs755622 GG genotype and G allele, rs2096525 T allele, rs755622/rs2096525 CT haplotype Zhang et al. [[128]]
Fibroblast growth factor receptor 1 oncogene partner (FGFR1OP) rs2301436 Yi et al. [[160]]