Figure 2

Spectral-domain optical coherence tomography and enhanced depth imaging-OCT findings in the eye with PIOL. The left column shows the SD-OCT images; the middle column, the EDI-OCT images; and the right column, the retinal thickness map. (A) Before treatment with methotrexate, (B) 1 month after initial methotrexate injection, (C) 6 months after initial injection, and (D) 9 months after initial injection. SD-OCT shows increased nodularity at the level of and above the retinal pigment epithelium (RPE) (yellow arrowheads), a separation of Bruch membrane from the RPE (arrows), damage of the RPE, disruption of the photoreceptor inner and outer segment (IS/OS) junction and external limiting membrane (ELM), multiple hyperreflective signals in the inner retina (white arrowheads), and foveal thinning (A, left). After initial injection of methotrexate, the hyperreflective infiltrations in the retina are markedly decreased, the RPE, the IS/OS junction, and ELM are restored, and the foveal thickness recovers (B to D, left). The subfoveal choroidal thickness gradually decreases in the EDI-OCT images (A to D, middle). A thickening of the retina is observed outside the central sector before treatment (A, right), but the retinal thickness gradually decreases outside the central sector after treatment (B to D, right).