Endophthalmitis after open globe injuries: changes in microbiological spectrum and isolate susceptibility patterns over 14 years

Jindal, Animesh; Pathengay, Avinash; Mithal, Kopal; Jalali, Subhadra; Mathai, Annie; Pappuru, Rajeev Reddy; Narayanan, Raja; Chhablani, Jay; Motukupally, Swapna R; Sharma, Savitri; Das, Taraprasad; Flynn, Harry W

doi:10.1186/1869-5760-4-5

Journal of Ophthalmic Inflammation and Infection

Table 1 Microbiological spectrum and antimicrobial susceptibilities in patients with endophthalmitis following open globe injuries

From: Endophthalmitis after open globe injuries: changes in microbiological spectrum and isolate susceptibility patterns over 14 years

Organism	Total/percentage(previous study)²	Total/percentage (current study)	Amikacin			Cefazolin			Ceftazidime			Chloramphenicol			Gentamicin			Gatifloxacin			Ciprofloxacin			Moxifloxacin			Vancomycin			Ofloxacin
			n	S	%	n	S	%	n	S	%	n	S	%	n	S	%	n	S	%	n	S	%	n	S	%	n	S	%	n	S	%
Gram-positive cocci	63/45.3	296/47.7	274	155	56.5	294	266	90.4	137	79	57.6	295	284	96.2	295	217	73.5	292	263	90.1	296	219	73.9	239	206	86.2	289	284	98.2	295	240	81.4
Coagulase-negative Staphylococcus	25/18	97/15.6	86	81	94.2	96	90	93.7	41	18	43.9	96	93	96.9	97	89	91.7	97	96	98.9	97	75	77.3	75	69	92	95	93	97.9	97	76	78.4
Staphylococcus aureus	5/3.6	11/1.8	11	11	100	11	11	100	5	3	60	11	11	100	11	10	90.9	11	10	90.9	11	5	45.4	10	8	80	11	11	100	11	6	54.5
Streptococcus sp.	30/21.6	172/27.7	163	52	31.9	172	154	89.5	81	54	66.6	172	166	96.5	172	108	62.7	169	143	84.6	172	127	73.8	143	119	83.2	168	165	98.2	171	143	83.6
Other gram-positive cocci	3/2.2	16/2.6	14	11	78.6	15	11	73.3	10	4	40.0	16	14	87.5	15	10	66.7	15	14	93.3	16	12	75.0	11	10	90.9	15	15	100	16	15	93.7
Gram-positive bacilli	24/17.3	117/18.8	114	109	95.6	115	63	54.7	75	12	16	117	109	93.1	117	112	95.7	117	116	99.1	116	108	93.1	101	99	98.0	114	109	95.6	117	116	99.1
Bacillus sp.	20/14.4	106/17.1	103	101	98.1	104	54	51.9	67	8	11.9	106	98	92.4	106	105	99.1	106	105	99.0	106	101	95.2	94	92	97.9	103	98	95.1	106	106	100
Other GPB	4/2.9	11/1.8	11	8	72.7	11	9	81.8	8	4	50	11	11	100	11	7	63.6	11	11	100	10	7	70	7	7	100	11	11	100	11	10	90.9
Gram negative organism	25/18	142/25	140	117	83.5	16	7	43.7	136	105	77.2	141	125	88.6	142	125	88.0	141	131	92.9	142	123	86.6	116	96	82.7	16	4	25	142	127	89.4
Pseudomonas sp.	10/7.2	16/2.6	16	12	75	1	0	0	16	11	68.7	16	5	31.2	16	12	75	16	12	75.0	16	11	68.7	13	8	61.5	1	0	0	16	11	68.7
Enterobacter sp.	2/1.4	25/4.0	25	22	88	5	2	40	23	21	91.3	25	24	96	24	23	95.8	25	24	96	25	24	96	19	19	100	5	2	40	25	24	96
E. coli	4/2.9	14/2.3	14	12	85.7	-	-	-	14	12	85.7	14	13	92.8	14	13	92.8	14	11	78.6	14	11	78.6	12	7	58.3	-	-	-	14	10	71.4
Haemophilus sp.	-	14/2.3	14	7	50	-	-	-	13	5	38.5	14	14	100	14	11	78.6	14	14	100	14	12	85.7	13	11	84.6	-	-	-	14	14	100
Other gram-negative organisms	9/6.5	73/11.8	71	64	90.1	10	5	50	70	56	80	72	69	95.8	74	66	89.2	72	70	97.2	73	65	89	59	51	86.4	10	2	20	73	68	93.2
Corynebacterium	5/3.6	10/1.6	5	4	80	10	9	90	3	0	0	10	9	90	10	9	90	10	9	90.0	10	7	70	8	6	75.0	10	10	100	10	9	90
Total bacteria	119/85.6	565/91.1	533	385	72.2	435	345	79.3	351	196	55.8	563	527	93.6	564	463	82.0	560	519	92.7	564	457	81.1	464	407	87.7	429	407	94.8	564	492	87.2
Total fungi	20/14.4	55/8.9	Not done
Aspergillus	9/6.5	20/3.2
Acremonium	1/0.7	1/0.32
Bipolaris	1/0.7	2/0.32
Cladosporium	1/0.7	2/0.32
Candida	-	3/0.48
Fusarium	2/1.4	1/0.16

All isolates were not tested for susceptibility to all antibiotics leading to ‘n’ being less than the total isolates. GPB, gram-positive bacilli; n, number of isolates tested for antibiotic susceptibility; S, number of isolates sensitive to the antibiotic.

Back to article page