Table 2 Summary statistics for endogenous C. dubliniensis endophthalmitis
From: Candida dubliniensis endophthalmitis: five cases over 15 years
Queensland series | Previous endogenous cases | Total | |
|---|---|---|---|
Number of patients | 5 | 3 | 8 |
Number of eyes involved | 6 | 3 | 9 |
Diagnosis and microbiology | |||
Vitreous taps | 5 | 1 | 6 |
Positive fungal vitreous taps | 3 (60%) | 1 (100%) | 4 (67%) |
Vitrectomy specimens | 7 | 3 | 10 |
Positive fungal vitrectomy specimens | 3 (43%) | 3 (100%) | 6 (60%) |
Ocular treatment | |||
Intravitreal amphotericin (number of eyes) | 3 (50%) | 2 (66%) | 5 (56%) |
Intravitreal voriconazole (number of eyes) | 4 (66%) | 0 | 4 (44%) |
Urgent vitrectomy | 1 (17%) | 1 (33%) | 2 (22%) |
Total number of vitrectomies | 8 | 3 | 11 |
Systemic treatment | |||
Empirical fluconazole | 2 (40%) | 1 (33%) | 3 (38%) |
Empirical voriconazole | 2 (40%) | 1 (33%) | 3 (38%) |
Definitive fluconazole therapy | 3 (60%) | 2 (66%) | 5 (56%) |
Definitive voriconazole therapy | 2 (40%) | 1 (33%) | 3 (33%) |
Mean duration of antifungal treatment (days) | 40 | 49 | 43 |
Outcomes | |||
Mean duration of follow-up (days) | 345 | 56 | 287 |
Final best-corrected visual acuity better than 20/80 | 5 (83%) | 2 (100%) | 7 (87%)a |
Final best-corrected visual acuity worse than 20/200 | 1 (17%) | 0 | 1 (13%)a |
Retinal detachment | 2 (33%) | 0 | 2 (22%) |
Enucleation/evisceration | 0 | 0 | 0 |
Mortality | 0 | 0 | 0 |