Figure 4

Patient 3. (Top) Day 27, the image appears normal with few abnormal hyperreflective signals that may indicate infiltrates as indicated by the arrowheads. Optos® wide-angle image shows clear vitreous following vitrectomy. (Center, upper) Day 72, the retina remains unchanged with a few hyperreflective signals as indicated by the arrowheads. No fundus image was available. (Center, lower) Day 175, evident hyperreflective signals are pointed by arrowheads. Layers are distorted, and RPE is disrupted as shown by the arrow. Inner segment/outer segment interface is no longer visible. There are new yellow lesions seen in the Optos® wide-angle image. A creamy lesion in the fovea is evident. (Bottom) Day 231, an increased amount of hyperreflective signals is found throughout the retina, and the overall reflectivity has also increased. RPE disruption has developed into pigment epithelial detachment as indicated by the arrow. Hyperreflective foci are found in the choroid as well. Optos® wide-angle image shows an increased degree of infiltration.