Table 3 Studies which demonstrated an increased incidence of malignancy with systemic immunosuppressive therapy in IED
Risk of malignancy | References |
|---|---|
8 malignancies were observed in 69 patients with ocular pemphigoid treated with cyclophosphamide and prednisone therapy (2 BCC, 2 SCC, 2 leukemias and 1 breast carcinoma) | [31] |
537 patients treated with systemic corticosteroids and/or immunosuppressive therapy found no significant difference between groups treated with immunosuppressive (n = 330) and the control (n = 207), p > 0.90 | [32] |
46 patients treated with systemic immunosuppressive agents for uveitis were examined for malignancy incidence during a 5-year follow-up and compared to patients who only received corticosteroid therapy; 8 malignancies occurred in the experimental group in comparison to 2 in the control (p < 0.05) | [33] |