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Table 1 Summary of published study

From: Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases

Authors

Makdoumi [ [25]]

Makdoumi [ [24]]

Morén [ [26]]

Iseli [ [27]]

Micelli Ferrari [ [28]]

Khan [ [29]]

Anwar [ [23]]

Price [ [34]]

Panda [ [35]]

Sorkhabi [ [36]]

Müller [ [37]]

Skaat [ [38]]

Years published

2010

2011

2010

2008

2009

2011

2011

2012

2012

2013

2012

2011

Design

Case series

Case series

Case report

Case series

Case report

Case series

Case series

Case series

Case series

Case Series

Case series

Case series

Level of evidence

3

3

3

3

3

3

3

3

3

3

3

3

Risk of bias

B

A

C

B

C

B

C

A

C

B

A

C

Number of patients

7

16

1

5

1

3

2

40

7

10

6

6

Age

66.7 (43 to 84)

42 (18 to 83)

25

43.2 (27 to 66)

78

42 (30 to 61)

38.5 (30 to 47)

57.1 (18 to 86)

50 (18 to 72)

62.4 (18 to 78)

41.8 (16 to 78)

46.3 (21 to 66)

Bacteria

4

12

0

3

1

0

1

24

0

9

1

3

Gram-positive

2

12

 

3

  

1

15

 

9

 

2

Gram-negative

2

   

1

  

9

  

1

1

Fungus

0

0

0

2

0

0

1

7

0

1

1

0

Yeas t

          

1

 

Mold

   

2

  

1

7

 

1

  

Protozoan

0

0

0

0

0

3

0

2

1

0

1

0

Acanthamoeba

     

3

 

2

1

 

1

 

Virus

0

0

0

0

0

0

0

1

0

0

0

0

Negative/not performed

3

4

1

0

0

0

0

6

6

0

3

3

Melting arrested

7

15

1

4

1

3

2

34

7

8

4

5

Cornea transplanted

1

0

0

3

0

2

1

5

0

1

2

1

Visual rehabilitation

   

2

     

(1 enucleation)

  

Tectonic aim

1

  

1

 

2

1

5

 

1

2

1

  1. Level 3 evidence?=?non-analytical studies; Risk of bias: A, low risk of bias; B, moderate risk of bias; C, high risk of bias.