Drug-induced uveitis

Journal of Ophthalmic Inflammation and Infection

Table 3 Quantitative assessment of causation of drug-induced uveitis using Naranjo algorithm

Route	Drug	Score per Naranjo criterion										Total score	Likelihood of causation
Route	Drug	1	2	3	4	5	6	7	8	9	10	Total score	Likelihood of causation
Systemic	Cidofovir	1	2	1	2	2	0	1	1	0	1	11	Definite
	Rifabutin	1	2	1	2	2	0	0	1	0	1	10	Definite
	Bisphosphonates	1	2	1	1	2	0	0	0	1	1	10	Definite
	Sulfonamides	1	2	1	2	2	0	0	0	1	1	10	Definite
	TNF-α inhibitors	1	2	1	2	0	0	0	0	0	1	7	Probable
	Fluoroquinolones	1	2	1	0	0	0	0	0	1	1	6	Probable
	DEC	1	2	1	0	−1	1	0	0	0	1	5	Probable
Topical	Metipranolol	1	2	1	2	2	0	0	1	0	1	10	Definite
	Glucocorticosteroids	1	2	1	2	0	1	0	0	1	1	9	Definite^a
	Brimonidine	1	2	1	2	2	0	0	0	0	1	9	Definite
	Prostaglandin analogs	1	2	1	2	2	0	0	0	0	1	9	Definite
Intraocular	Cidofovir	1	2	1	2	2	0	1	1	0	1	11	Definite
	Anti-VEGF agents	1	2	1	2	2	1	0	0	1	1	11	Definite
	Triamcinolone acetonide	1	2	1	2	−1	0	0	0	1	1	7	Probable
Vaccines	BCG	1	2	1	2	2	0	0	0	0	1	9	Definite
	Influenza	1	2	1	0	2	0	0	0	0	1	7	Probable
	MMR	1	2	1	0	2	0	0	0	0	1	7	Probable
	Hepatitis B	1	2	0	0	2	0	0	0	0	1	6	Probable
	Varicella	1	2	1	0	−1	0	0	0	0	1	4	Possible

BCG, bacille Calmette-Guérin; DEC, diethylcarbamazine; MMR, measles, mumps, and rubella; TNF, tumor necrosis factor. ^aOlder reports, some of which found an association with latent syphilis infection.