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Table 3 Quantitative assessment of causation of drug-induced uveitis using Naranjo algorithm

From: Drug-induced uveitis

Route Drug Score per Naranjo criterion Total score Likelihood of causation
1 2 3 4 5 6 7 8 9 10
Systemic Cidofovir 1 2 1 2 2 0 1 1 0 1 11 Definite
Rifabutin 1 2 1 2 2 0 0 1 0 1 10 Definite
Bisphosphonates 1 2 1 1 2 0 0 0 1 1 10 Definite
Sulfonamides 1 2 1 2 2 0 0 0 1 1 10 Definite
TNF-α inhibitors 1 2 1 2 0 0 0 0 0 1 7 Probable
Fluoroquinolones 1 2 1 0 0 0 0 0 1 1 6 Probable
DEC 1 2 1 0 −1 1 0 0 0 1 5 Probable
Topical Metipranolol 1 2 1 2 2 0 0 1 0 1 10 Definite
Glucocorticosteroids 1 2 1 2 0 1 0 0 1 1 9 Definitea
Brimonidine 1 2 1 2 2 0 0 0 0 1 9 Definite
Prostaglandin analogs 1 2 1 2 2 0 0 0 0 1 9 Definite
Intraocular Cidofovir 1 2 1 2 2 0 1 1 0 1 11 Definite
Anti-VEGF agents 1 2 1 2 2 1 0 0 1 1 11 Definite
Triamcinolone acetonide 1 2 1 2 −1 0 0 0 1 1 7 Probable
Vaccines BCG 1 2 1 2 2 0 0 0 0 1 9 Definite
Influenza 1 2 1 0 2 0 0 0 0 1 7 Probable
MMR 1 2 1 0 2 0 0 0 0 1 7 Probable
Hepatitis B 1 2 0 0 2 0 0 0 0 1 6 Probable
Varicella 1 2 1 0 −1 0 0 0 0 1 4 Possible
  1. BCG, bacille Calmette-Guérin; DEC, diethylcarbamazine; MMR, measles, mumps, and rubella; TNF, tumor necrosis factor. aOlder reports, some of which found an association with latent syphilis infection.