Skip to main content

Table 1 The Naranjo scoresheet for assessing the association between a medication and an adverse reaction

From: Drug-induced uveitis

Question Yes No Not known Score
1. Are there previous conclusive reports on this reaction? +1 0 0  
2. Did the adverse event appear after the suspected drug was administered? +2 −1 0  
3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? +1 0 0  
4. Did the adverse reaction reappear when the drug was readministered? +2 −1 0  
5. Are there alternative causes (other than the drug) that could on their own have caused the reaction? −1 +2 0  
6. Did the reaction reappear when a placebo was given? −1 +1 0  
7. Was the drug detected in the blood (or other fluids) in concentrations known to be toxic? +1 0 0  
8. Was the reaction more severe when the dose was increased, or less severe when the dose was decreased? +1 0 0  
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure? +1 0 0  
10. Was the adverse event confirmed by any objective evidence? +1 0 0  
TOTAL  
  1. The maximal possible score is 13. Naranjo scores of 9 or higher imply a definite association, scores of 5 to 8 a probable association, scores of 1 to 4 a possible association, and scores of 0 make an association doubtful.