Table 1 The Naranjo scoresheet for assessing the association between a medication and an adverse reaction
From: Drug-induced uveitis
Question | Yes | No | Not known | Score |
|---|---|---|---|---|
1. Are there previous conclusive reports on this reaction? | +1 | 0 | 0 | Â |
2. Did the adverse event appear after the suspected drug was administered? | +2 | −1 | 0 |  |
3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? | +1 | 0 | 0 | Â |
4. Did the adverse reaction reappear when the drug was readministered? | +2 | −1 | 0 |  |
5. Are there alternative causes (other than the drug) that could on their own have caused the reaction? | −1 | +2 | 0 |  |
6. Did the reaction reappear when a placebo was given? | −1 | +1 | 0 |  |
7. Was the drug detected in the blood (or other fluids) in concentrations known to be toxic? | +1 | 0 | 0 | Â |
8. Was the reaction more severe when the dose was increased, or less severe when the dose was decreased? | +1 | 0 | 0 | Â |
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure? | +1 | 0 | 0 | Â |
10. Was the adverse event confirmed by any objective evidence? | +1 | 0 | 0 | Â |
TOTAL | Â | |||