Spectral domain optical coherence tomography horizontal scans and thickness maps at various study time points. Two study subjects presented with macular edema at baseline. Both patients had posterior uveitis at baseline and were randomized to group 2 (subconjunctival group). At baseline, subject 5 had active uveitis and was receiving no systemic immunosuppressants (study category 1). Subject 23 had active uveitis at baseline and was receiving prednisone 20 mg/day (study category 2); the prednisone dose was tapered to 15 mg/day at month 3 and to 7.5 mg/day at month 6. Sirolimus was injected at days 0, 60, and 120 (yellow asterisks). Noticeable reduction in macular edema and central macular thickness was consistently observed 14 to 30 days following the injection with diminished response observed in the visits following day 120.