Fig. 4

Clinically stable lesions that have remained unchanged on spectral domain optical coherence tomography scans during multiple visits. This figure shows magnified SD-OCT scans. The arrows point to the lesions. Top left (lesion 19): focal retinal pigment epithelium (RPE) disruption remained unchanged over a period of 16 months. Top right (lesion 2): focal irregularity of RPE and photoreceptor IS/OS junctions with choroidal thinning, unchanged over a period of 8 months. Bottom left (lesion 20): RPE elevation with sub-RPE signal, unchanged over a period of 16 months. Bottom right (lesion 15): focal disruption of photoreceptor IS/OS junctions with thinning of the ONL, unchanged over a period of 6 months. Repeated OCT scans at subsequent visits did not change in appearance compared to the images illustrated in these figures, and therefore, are not shown. SD-OCT spectral domain optical coherence tomography, RPE retinal pigment epithelium, IS/OS inner segment/outer segment, ONL outer nuclear layer, mos months