Table 1 Clinical summary, management, and outcome of all reported cases of isilated Nocardia scleritis
Sl no. | Author | Eye | Age | Sex | Predisposing factor | Duration of symptoms | Presenting VA | Final VA | Treatment—medical | Treatment—surgical | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Kattan [3] | OD | 63 | F | Scleral buckle, cataract surgery | 2 weeks | 1/200 | NA | Topical and TMP-SMX (iv) | Eviseration | Eviseration |
2 | King [5] | OD | 77 | M | Scleral buckle, cataract surgery | 14 weeks | 20/60 | 20/40 | Topical 10% sulphacetamide, TMP-SMX (iv) | Buckle removal | Resolved |
3 | Brooks [4] | OS | 90 | F | Cataract surgery | 5 weeks | 20/80 | NA | Topical amikacin, topical and oral TMP-SMX | Surgical debridement, scleral patch graft | Resolved |
4 | Basti [2] | OD | 58 | M | Injury with vegetable material, steroids | 1 month | 20/200 | 20/40 | Cefazolin (systemic and topical) | Nil | Resolved |
5 | Knox [8] | OS | 83 | M | Explantation of exposed buckle, steroids | NA | 20/100 | 20/60 | Topical amikacin 2.5%, TMP-SMX 160/800 | Nil | Resolved |
6 | Choudhry [10] | OS | 54 | M | Steroids | 7 Weeks | 20/30 | NA | Cefazolin (systemic and topical), TMP-SMX 160/800, 10% sulphacetamide | Surgical debridement | Worsened and lost to follow up |
7 | Das [9] | OS | 40 | F | Mud splash, steroids | 7 weeks | 20/20 | 20/20 | Topical TMP-SMX 160/800, amikacin 2.5%, amoxycillin/clavulanate (800/125 mg) | Nil | Resolved |
8 | Seth [6] | OD | 80 | F | Subtenon steroid | 3 months | 20/400 | CF 1 m | Topical trimetho prim/polymixin B, minocycline 100 mg/day | Scleral exploration and biopsy and bovine pericardium patch graft | Resolved |
9 | Jain [11] | OD-2 OS-1 | 60.66 ± 7.36 | M-3 | Scleral buckle—n = 2 | 1–2 months | 20/125–20/400 | 20/80–20/400 | Topical amikacin—all cases, TMP-SMX 160/800—n = 2 | Debridement n = 1 | Resolved—all |
10 | DeCroos [12] | OD-8 OS-3 | 56.8 ± 13 | M-11 | Injury with organic material—n = 5 | 30.4 ± 16.8 days | Mean BCVA—20/502 | Mean BCVA—20/399 | Topical amikacin/ciprofloxacin/cefazolin—n = 11 | Surgical debridement—n = 8; conjunctival excision—n = 2; tissue adhesive—n = 1 | Resolved |
Scleral buckle—n = 1 | Systemic amikacin—n = 3 | ||||||||||
PPV—n = 1 | |||||||||||
11 | Maruo [13] | OS | 78 | M | Cataract surgery | 2 months | 20/30 | 20/16 | Topical tobramycin, moxifloxacin, oral TMP-SMX | Debridement | Resolved |