Fig. 2

Combined fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT) images through the active lesion(s). The green frame (left panel) indicates the borders of the scanned area. The position marker corresponds to the retinal location through which the displayed OCT scan is obtained. In the right eye (a–c), in acute stage (a), there is an ill-defined area of increased autofluorescence (left panel) with fuzzy area of hyperreflectivity in outer retinal layers (white arrows) involving the retinal pigment epithelium (RPE), photoreceptor outer segment tips (POST), photoreceptor inner segment–outer segment (IS–OS) junction, external limiting membrane (ELM), and outer nuclear layer (ONL) (right panel). The inner retinal layers showed mild distortion. There was absence of any backscattering from the inner choroid (red arrows). About 2 weeks later (b), as the lesions started healing, they became well defined with a thin hypoautofluorescent border and predominantly hyperautofluorescence centrally in the right eye (left panel). The SD-OCT showed irregular knobby elevations (white arrows) of the outer retinal layers (right panel). The RPE, POST, IS–OS junction, and ELM could not be distinguished. There was an increased reflectance from the choroidal layers (red arrows) due to disappearing RPE–photoreceptor complex. Three months later (c), as the lesions healed further, they appeared stippled with predominantly hypoautofluorescence (left panel). The SD-OCT scan showed loss of RPE, POST, IS–OS junction, and ELM (white arrows) (right panel). The increased backscattering of the choroid persisted (red arrows). d–f Similar changes were seen in the left eye in acute (d), healing (e), and healed (f) stages of active lesions of SLC