Table 1 Paraneoplastic neuro-retinopathy patients with anti-optic nerve and anti-retinal AAbs
Number | Sex | Age | Diagnosed cancer | Onset of cancer | Onset of visual symptoms | Reported optic nerve findings | Anti-optic nerve AAbs | Anti-retinal AAbs |
|---|---|---|---|---|---|---|---|---|
1 | F | 43 | Brain venous angioma | 2006 | 2004 | 46 k | 46 k | |
2 | F | 43 | Breast | Apparent temporal pallor | 27 k, 35 k | 27 k | ||
3 | F | 50 | Breast | 2005 | 2007 | Bilateral temporal optic disc pallor and juxtapapillary atrophic changes OD > OS | 46 k | 46 k |
4 | F | 59 | Breast | 1999 | 2006 | Glaucoma | 24 k,36 k, 50 k, 70 k | 46 k, 62 k, 70 k, 112 k |
5 | F | 55 | Breast | Optic neuropathy | 46 k, 82 k | 46, 66 k, 82 k | ||
6 | F | 68 | Breast | Sequential episodes of optic neuropathies | 30, 42 k low | negative | ||
7 | F | 58 | Breast | 23 k, 27 k | 23 k, 25 k, 32 k, 33 k | |||
8 | F | 60 | Breast | 2008 | 62 k | 35 k,38 k low | ||
9 | F | 47 | Breast metastatic to brain | Congenital optic nerve change with tilting OS, | 30 k, 36 k | 46 k | ||
10 | F | 56 | Cervix | 1983 | 2009 | Slightly enlarged cup to disc ratio bilaterally | 36 k, 42 k, 96 k | 30 k |
11 | F | 58 | Cervix | 46 k | ||||
12 | M | 64 | Colorectal | 2004 | 2008 | 23 k | 40 k, 44 k, 46 k, 60 k | |
13 | F | 71 | Endometrium metastatic | 46 k | 46 k high | |||
14 | F | 61 | Glioblastoma | Homonymous hemianopsia OD, hemi between the macula and optic nerve | 35 k low | 35 k low | ||
15 | M | 43 | Malignant hepatoma | 2006 | 2005? | Optic atrophy | 33 k | 33 k |
16 | F | 65 | Lung | 2008 | 2006 | 7 proteins 35–50 k | 28 k, 46 k | |
17 | F | 78 | Lung non-small cell carcinoma | Holes in both capsules | 30 k | 30 k | ||
18 | F | 55 | Lymphoma CNS | 2006 | 70 k | 70 k | ||
19 | F | 83 | Melanoma | Optic neuropathy | 28 k | 47 k, 70 k, 112 k | ||
20 | F | 79 | Melanoma | 46 k, 45 k | 46 k | |||
21 | M | 61 | Melanoma | 30 k | 30 k | |||
22 | F | 72 | Ovarian | 46 k | 35 k, 46 k | |||
23 | M | 77 | Prostate | 1996 | 2003 | RNFL slightly thinned temporally OD; | 61 k, 62 k | 30 k, 67 k, 112 k |
24 | M | 79 | Prostate | 2005 | 2000 | 41 k | negative | |
25 | M | 85 | Prostate and adrenal adenoma | 2002 | 24–25 k | negative | ||
26 | M | 77 | Prostate and skin cancers | 2001 | 2005 | 24–26 k | negative | |
27 | F | 61 | Rectal | 2008 | 2003 | Very enlarged blind spots OU | 46 k | 46 k |
28 | F | 35 | Renal | ~2008 | 46 k | 30 k, 46 k, 90 k, 140 k | ||
29 | F | 70 | Thyroid | 2006 | Vertical optic nerve head cupping OS > OD, in OS with peripapillary atrophy | 90 k | 49–50 k, 90 k | |
30 | M | 72 | Thyroid benign | 2004 | ~1973 | 36 k, 54 k | 27 k, 30 k, 33 k |