Table 1 Patient characteristics and medications
From: Three cases of recalcitrant Paecilomyces keratitis in Southern California within a short period
Patient Characteristics | Case 1 | Case 2 | Case 3 |
|---|---|---|---|
Age (Years) | 72 | 87 | 77 |
Gender | Female | Female | Male |
Ocular History | Contact lens-related corneal ulcer OD | Recurrent herpetic anterior uveitis OS; bilateral primary open-angle glaucoma | PKP for corneal ulcer complicated by descemetocele formation OD; bilateral glaucoma |
Contact Lens Wear | Yes | No | No |
Baseline VA (OD; OS) | N/A | 20/50; 20/60 | CF at 2 ft; CF at 3 ft |
Presenting VA (OD; OS) | 20/600; 20/30 | 20/30; 20/500 | HM; CF at 3 ft |
Presenting Symptoms | Severe eye pain and worsening vision | Severe eye pain and worsening vision | Persistent epithelial defect and occasional eye pain |
Topical Medications | Vancomycin 25 mg/mL Tobramycin 15 mg/mL Moxifloxacin Prednisolone Acetate 1% Trimethoprim / Polymyxin Natamycin | Loteprednol Travoprost Brimonidine / Timolol Besifloxacin Erythromycin Natamycin Trimethoprim / Polymyxin Moxifloxacin Neomycin / Polymyxin b / Dexamethasone | Cenegermin Timolol Brimonidine Latanoprost Moxifloxacin Loteprednol Natamycin Prednisolone Acetate 1% |
Intraocular Injections | Voriconazole 100mcg/0.1 cc Amphotericin B 5mcg/0.1 ml | Voriconazole 100mcg/0.1 cc Amphotericin B 5mcg/0.1 ml | None |
Oral Medications | Voriconazole 200 mg BID Doxycycline 100 mg BID | Voriconazole 200 mg BID Doxycycline 100 mg BID Valaciclovir 1000 mg QD | Voriconazole 200 mg BID Doxycycline 100 mg BID |
Final Medication Regimen Before Resolution | Posaconazole 300 mg BID for 2 weeks, then QD for 2 weeks | Posaconazole 300 mg BID for 2 weeks, then QD for 2 weeks | Posaconazole 300 mg BID for 3 weeks |