Skip to main content
Journal of Ophthalmic Inflammation and Infection

Table 3 Characteristics and common features of sarcoid uveitis in adults, children and Blau Syndrome/ Early Onset Sarcoidosis (BS/EOS)

From: Ocular sarcoidosis in adults and children: update on clinical manifestation and diagnosis

 

Study

nbr of patients in the study with ocular manifestation of sarcoidosis or BS/EOS

Number of all patients in the study

Age, years, median of patients’ age with ocular manifestations of sarcoidosis or BS/EOS; for BS/EOS median age at ocular onset and age at study baseline

Bilateral

Granulomatous

Mutton-fat keratic precipitates

Mutton-fat KPs, iris nodules, or both

Non granulomatous

Adults

SUN, 2021

278b

2684

49 (IQR 39–61)

82%

-

23%

35%

-

Acharya,2018

167c

884

49 (IQR 39—60)

86%

-

35%

46%

-

Coulon, 2019

194d

194

52.1 ± 17.8

77.8%

60%

-

-

-

Niederer, 2021

362e

362

46 (IQR 35–57)

87%

48%

-

-

-

Allegri, 2022

235

235

mean age 52

85%

52%

-

-

-

Children > 5 years

Choi, 2011

13f

460

12 (range: 5 to 16)

-

31%

-

-

62%

Morelle, 2019

9b

147

-, mean age 10.5 (range: 7–14)

100%

23%

-

-

-

Waduthantri S, 2021

8 g

73

mean age 12 (range: 5–15)

-

-

-

-

-

Blau Syndrome / Early Onset Sarcoidosis

Sarens, 2018

38

50

5 (range 0,5- 48); at study baseline: 17 (range 2–56)

97%

-

-

-

-

Kumrah, 2022

9

11

4 (range: 2–26); median age at dignosis: 9 (range: 2–26)

100%

44%

-

11% only iris nodules specified

11%

Matsuda, 2020

38

50

-, -; all patients in the study: mean 26.7 (range 0–61)

-

-

-

-

-

Wu,2019

7

7

5,5 (range 2-24y), at study baseline: 10,5 (range: 4–34)

-

-

-

-

-

Babu, 2020

7

7

-, at study baseline: 9 (range 2,5–25)

71%i

71%j

14%

-

-

Rosé, 2015

25

31

4.4 (range 0,5–22); at study baseline 16.5 (range: 1.9–58)

96%

-

-

-

-

 

No keratic precipitates

Anteriora uveitis

Intermediatea uveitis

Posteriora uveitis

Panuveitis a

Multifocal choroiditis

Retinal vascular inflammationh

Solitary choroidal nodule (optic disc nodules or granulomas)

Adults

52%

40%

19%

4%

37%

30%

18%

2% (-)

-

20%

3%

9%

67%

45%

36%

3% (4%)

-

34%

10%

7%

49%

40%

30%

-

-

-

-

-

-

43%

21%

11% isolated choroidal or optic nerve granuloma

-

52%

10%

29%

8%

-

-

-

Children > 5 years

8%

-

-

-

-

54%

31%

-

-

77%

-

-

23%

-

-

-

-

12.50%

-

25%

62.50%

-

-

-

Blau Syndrome / Early Onset Sarcoidosis

-

29%

-

-

51%

39%

0%

- (12%) peripapillary nodules

-

33%

-

-

67%

67%

11%

-

-

-

-

-

-

-

-

-

-

14%

-

-

85%

-

-

-

-

29%

-

-

43%

-

-

14% (-)

-

-

-

-

-

-

-

-

  1. IQR interquartile range; data not available
  2. aanatomic class (SUN)/ type by anatomic location (Acharya, 2018)
  3. bsarcoidosis-associated uveitis
  4. cincluding 98 patients with definite ocular sarcoidosis and 69 patients with presumed ocular sarcoidosis according to IWOS 2009 criteria
  5. dincluding 145 with biopsy-proven and 49 with presumed sarcoid uveitis following the WASOG/ATS/ERS criteria
  6. eincluding definite or presumed ocular sarcoidosis according to IWOS 2009 criteria
  7. fincluding 4 definite, 3 presumed, or 6 probable sarcoidosis according to selfestblished scoring system
  8. g8 patients with presumed ocular sarcoidosis and 2 patients with sarcoid scleritis
  9. hrefered to as: retinal vascular sheathing or periphebitis or vasculitis
  10. iat least 71%, no data available on bilaterality for 2 other patients with only conjunctival granulomas
  11. jand additionally 29% with only conjunctival granulomas
  12. - no data available
Back to article page