Multimodal imaging of refractory Candida chorioretinitis progressing to endogenous endophthalmitis
© Lavine and Mititelu. 2015
Received: 16 February 2015
Accepted: 28 July 2015
Published: 8 August 2015
Endogenous fungal endophthalmitis is a serious vision-threatening condition that occurs in immunosuppressed patients with candidemia.
We report a complicated case of Candida albicans chorioretinitis that progressed to endophthalmitis. The patient required intravitreal and systemic anti-fungal medications with pars plana vitrectomy for successful treatment. Multimodal imaging using fundus photography, fluorescein angiography, spectral domain optical coherence tomography, and fundus autofluorescence was obtained throughout treatment. These modalities localized the Candida infection in the choroid, penetrating Bruch’s membrane, the retinal pigment epithelium, and the retina to enter the vitreous cavity. This infectious route resulted in loss of the retinal pigment epithelium, photoreceptors, and outer retinal layers, with scar formation that resulted in vision loss and increased future risk of choroidal neovascular membranes.
Multimodal imaging of C. albicans chorioretinitis allows for accurate diagnosis, assessment of response to therapy, and prognosis for visual recovery and future complications.
KeywordsEndophthalmitis Chorioretinitis Candida albicans Optical coherence tomography Fundus autofluorescence Fluorescein angiography
Endogenous fungal endophthalmitis is a serious vision-threatening condition. In the United States, yeasts are the most common causative organism, accounting for 75 % of cases . Among yeasts, Candida albicans is the most common pathogen . In 14 % of patients with Candidemia, ocular complications occur . The majority of these patients develop chorioretinitis with 1.6 % of patients advancing to endophthalmitis . In patients with yeast endophthalmitis, visual acuity outcomes can be poor with only 56 % of eyes achieving vision of 20/200 or better .
This case report describes the clinical course of a patient with C. albicans chorioretinitis that progressed to recalcitrant endophthalmitis. Using multimodal imaging, we chronicle the features of chorioretinitis through multiple medical and surgical therapies.
A 48-year-old male presented with blurred central vision in his right eye. Past ocular history included bilateral pseudophakia. Medical history was significant for a 4-year history of rheumatoid arthritis on oral prednisone 15 mg daily and a recent history of nephrolithiasis. One month prior to presentation, his nephrolithiasis was treated with extracorporeal shock wave lithotripsy and ureteral stent placement. One week after lithotripsy, urine cultures grew C. albicans and the patient started oral fluconazole 300 mg daily. For 3 weeks, the patient complained of blurred central vision in the right eye without redness or floaters.
The patient was lost to follow-up and presented 2 weeks later with new floaters OD. On examination, visual acuity remained 20/100 OD, the anterior segment was unchanged, and the posterior segment displayed vitritis with a fluffy chorioretinal lesion (Fig. 1d). Candida endophthalmitis was diagnosed, the patient received a same-day intravitreal injection of amphotericin B (5 μg/0.1 mL) and was placed on intravenous amphotericin B (0.1 mg/mL). The patient developed acute kidney injury (AKI) 1 week after initiation of treatment, requiring discontinuation of amphotericin B and resumption of fluconazole. At this time, blood cultures were negative for C. albicans.
We present a complicated case of C. albicans chorioretinitis that progressed to endogenous endophthalmitis, requiring multiple local and systemic antifungal medications and PPV. Risk factors for endogenous yeast endophthalmitis include hospitalization, surgery, cancer, diabetes, intravenous drug use, and indwelling catheters . Risk factors for this particular case include recent lithotripsy of renal calculi and immunosuppression from prednisone therapy . It is common for lithotripsy to cause asymptomatic Candiduria; in this immunocompromised patient, the Candiduria likely caused Candidemia, leading to chorioretinitis. In a prospective, multicenter study of 11 patients with chorioretinitis, none progressed to endophthalmitis . Although limited by a small number of patients, this study suggests that our patient had been initially underdosed with fluconazole 300 mg daily. Once Candida endophthalmitis developed, our patient received both intravitreal and systemic amphotericin B. However, therapy was changed to oral and intravitreal voriconazole after AKI from amphotericin B. Voriconazole is effective against fluconazole-resistant C. albicans strains and has excellent ocular penetration . It has been shown that Candida species preferentially infect the vitreous and form loculated microabscesses, which may ultimately require vitrectomy for clearance . In the case of our patient, despite stabilization of the infection with aggressive systemic and intravitreal antifungal management, PPV was required to decrease the fungal load.
To our knowledge, this is the first report using FA, SD-OCT, and FAF to follow a case of Candida chorioretinitis progressing to endophthalmitis. Our patient initially presented with a white, elevated chorioretinal lesion (Fig. 1a). FA displayed a foveal lesion with early hyperfluorescence and late staining (Fig. 1b, c), consistent with prior reports of Candida chorioretinitis . The lack of late leakage rules out choroidal neovascularization (CNV). However, the presence of vascular leakage near the lesion does not exclude Candida chorioretinitis as the cause of the macular lesion, as this angiogram pattern has been documented .
SD-OCT and FAF imaging help the clinician determine the route of infectious seeding, the etiology and treatment options, and the prognosis for visual recovery. SD-OCT findings early in the course of treatment demonstrated an elevated, hyperreflective lesion at the retina-vitreous interface with poorly defined borders and obscured underlying retinal detail (Fig. 2a). At the edge of the lesion, elevation of the RPE suggests that the lesion originated in the choroid. We suspect that this lesion is a focus of inflammatory and infectious material that locally infiltrated the macula. As the lesion was treated, the inner retinal hyperreflective lesion regressed but the borders demonstrated a persistently elevated, discontinuous RPE (Fig. 2b, c). These characteristics suggest that the Candida infection progressed via choroidal infiltration through Bruch’s membrane and RPE, into the retina and the vitreous. We hypothesize that this seeding is secondary to spread through the short posterior ciliary artery rather than through the central retinal artery [9,10] because of the initial presentation as an indolent chorioretinitis instead of an explosive endophthalmitis. Cho et al. previously evaluated Candida chorioretinitis with SD-OCT, demonstrating RPE elevation and outer retinal destruction in early, active lesions and inner retinal hyperreflective elevation with blockage in late, inactive lesions . Our lesion showed SD-OCT characteristics of both early, active and late, inactive chorioretinitis stages as it evolved during the clinical course. We hypothesize that clinically and through multimodal imaging, our lesion demonstrated active features, especially given its pronounced hyperfluorescence on FA and its regression with treatment.
Vision loss in our patient occurred primarily due to photoreceptor loss and scarring. SD-OCT showed loss of outer plexiform, outer nuclear, external limiting membrane, and inner segment/outer segment (IS/OS) layers, and an area of thickened and hyperreflective subretinal scar tissue (Fig. 3c). FAF displayed lack of fluorescence centrally, indicating RPE destruction and confirming the presence of scar tissue (Fig. 3b). Not including the ring of hypofluorescent peripapillary atrophy, the scar is one disk diameter, which is twice the initial infiltrate. Thus, our imaging demonstrates centrifugal scar expansion and photoreceptor loss as the primary causes for vision loss. In other reports, vision loss occurred in the presence of macular edema [12,13], a clinical finding absent in this case.
Our patient remains at risk for further vision loss from potential CNV. FAF and SD-OCT imaging (Fig. 3) showed inflammatory and infectious destruction of Bruch’s membrane and RPE destruction, creating a locus for potential development of CNV. We suspect that once the integrity of the RPE layer has been violated, there is endophytic spread of the infection into the retina and vitreous, which increases the risk of further visual loss and the chance of requiring surgery. We emphasize that both SD-OCT and FAF highlight findings that were only previously demonstrable on histopathology. More importantly, they serve as non-invasive and readily available tools for monitoring progression and for informing the clinician regarding the effectiveness of various treatment modalities and prognosis for visual recovery.
acute kidney injury
choroidal neovascular membrane
inner segment/outer segment
pars plana vitrectomy
retinal pigment epithelium
spectral domain optical coherence tomography
Neither author has received any grant support or research funding for this project.
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- Lingappan A, Wykoff CC, Albini TA et al (2012) Endogenous fungal endophthalmitis: causative organisms, management strategies, and visual acuity outcomes. Am J Ophthalmol 153:162–166.e1, doi: 10.1016/j.ajo.2011.06.020PubMedView ArticleGoogle Scholar
- Oude Lashof AML, Rothova A, Sobel JD et al (2011) Ocular manifestations of candidemia. Clin Infect Dis 53:262–268. doi:10.1093/cid/cir355 PubMedView ArticleGoogle Scholar
- Greenwald BD, Tunkel AR, Morgan KM et al (1992) Candidal endophthalmitis after lithotripsy of renal calculi. South Med J 85:773–774PubMedView ArticleGoogle Scholar
- Donahue SP, Greven CM, Zuravleff JJ, Eller AW (1994) Intraocular candidiasis in patients with candidemia: clinical implications derived from a prospective multicenter study. Ophthalmology 101(7):1302–1309PubMedView ArticleGoogle Scholar
- Riddell J, Comer GM, Kauffman CA (2011) Treatment of endogenous fungal endophthalmitis: focus on new antifungal agents. Clin Infect Dis 52:648–653. doi:10.1093/cid/ciq204 PubMedView ArticleGoogle Scholar
- Rao NA, Hidayat AA (2001) Endogenous mycotic endophthalmitis: variations in clinical and histopathologic changes in candidiasis compared with Aspergillosis. Am J Ophthalmol 132:244–251PubMedView ArticleGoogle Scholar
- Vianna RNG, Filho JPS, Deschênes J, Burnier MN Jr (2005) Bilateral Candida chorioretinitis: involvement of the second eye after 3 years. Can J Ophthalmol 40:75–78. doi:10.1016/S0008-4182(05)80122-X PubMedView ArticleGoogle Scholar
- Alexandridou A, Reginald AY, Stavrou P, Kirkby GR (2002) Candida endophthalmitis after tattooing in an asplenic patient. Arch Ophthalmol 120:518–519PubMedView ArticleGoogle Scholar
- Griffin JR, Pettit TH, Fishman LS, Foos RY (1973) Blood-borne Candida endophthalmitis. Arch Ophthalmol 89:450–456. doi:10.1001/archopht.1973.01000040452002 PubMedView ArticleGoogle Scholar
- Kawanishi Y, Morinobu T, Shirakawa K, Ueno Y (1987) Histopathological studies of endogenous fungal endophthalmitis. Folia Ophthalmol Jpn 38:204–211Google Scholar
- Cho M, Khanifar AA, Chan RVP (2011) Spectral-domain optical coherence tomography of endogenous fungal endophthalmitis. Retin Cases Brief Rep 5:136–140. doi:10.1097/ICB.0b013e3181cc2146 PubMedView ArticleGoogle Scholar
- Chang Y, Yang CS, Lee FL, Lee SM (2012) Voriconazole for Candida endophthalmitis. OPHTHA 119:2414–2415, e4. doi: 10.1016/j.ophtha.2012.06.020View ArticleGoogle Scholar
- Chavan R, Mustafa MZ, Narendran N et al (2012) A case of Candida albicans endophthalmitis with no predisposing risk factors and a distant source of infection. Case Rep Ophthalmol 3:277–282. doi:10.1159/000342135 PubMed CentralPubMedView ArticleGoogle Scholar