From: A retrospective review of oral low-dose sirolimus (rapamycin) for the treatment of active uveitis
Case | Age | Sex | History | Diagnosis | Previous therapy | Reason for sirolimus |
---|---|---|---|---|---|---|
1 | 67 | M | Panuveitis OU with CME OD > OS treated with topical steroids. | Sarcoidosis | Topical ketorolac, topical prednisolone | Patient wanted to avoid oral prednisone |
2 | 39 | M | Bilateral recurrent anterior uveitis and scleritis treated with multiple orbital floor steroid injections. | Sarcoidosis | Subtenon triamcinolone, oral prednisone | Frequent flares |
3 | 31 | F | Chronic anterior uveitis with CME OD previously treated with prednisone and methotrexate. Poor control of inflammation with frequent flares. | Idiopathic | Subtenon triamcinolone, oral prednisone, oral methotrexate | Uncontrolled inflammation with previous regimen |
4 | 26 | M | Bilateral chronic intermediate uveitis. Treated for Lyme disease by infectious diseases. | Secondary to Lyme disease | Oral prednisone, oral methotrexate | Uncontrolled inflammation with previous regimen |
5 | 54 | M | Granulomatous anterior uveitis with vasculitis and choroidal infiltrates OD s/p repair of ruptured globe and eventual enucleation OS. | Sympathetic ophthalmia | IV methylprednisolone, oral prednisone | Uncontrolled inflammation despite maximal dose of oral prednisone |
6 | 61 | M | Panuveitis OU treated with orbital floor steroid injections and high-dose oral corticosteroids. History of hepatitis C and aseptic meningitis. | Sarcoidosis | Subtenon triamcinolone, oral prednisone | Avoid higher doses of oral prednisone |
7 | 79 | F | Panuveitis with CME OD > OS treated with oral corticosteroids. History of chronic anemia. | Idiopathic | Oral prednisone | Avoid higher doses of oral prednisone |
8 | 21 | M | Recurrent panuveitis treated with high doses of oral corticosteroids. | HLA B27 positive | Oral prednisone | Uncontrolled inflammation despite maximal dose of oral prednisone |